摘要
随着肥胖以及其他代谢综合征发病率的增高,目前非酒精性脂肪性肝病(NAFLD)已经成为最常见的慢性肝脏疾病之一。越来越多的研究表明NAFLD是肝细胞癌的危险因素之一,但NAFLD发展成为肝细胞癌的机制尚未完全阐明。近年研究显示肠道微生态失衡、炎症反应、脂肪因子、胰岛素抵抗、高胰岛素血症、脂肪祖细胞以及遗传基因的突变等参与了NAFLD相关肝癌的发生。现阶段针对NAFLD的治疗措施主要有运动饮食干预、胰岛素增敏剂、抗氧化剂、益生菌以及降脂药等,这些治疗方法能否有效预防NAFLD相关肝细胞癌尚不清楚。综述了近年来NAFLD相关肝细胞癌的流行情况、发病机制、预防、监测及筛查。
With the increase in the incidence rates of obesity and other metabolic syndromes,nonalcoholic fatty liver disease(NAFLD)has become one of the most common chronic liver diseases.More and more studies have shown that NAFLD is one of the risk factors for hepatocellular carcinoma(HCC),but the mechanism of NAFLD in HCC remains unclear.Recent studies have found that intestinal microflora imbalance,inflammatory response,adipokines,insulin resistance,hyperinsulinemia,adipose progenitor cells,and genetic mutation are involved in the development of NAFLD-related HCC.Major treatment methods for NAFLD include exercise and diet intervention,insulin sensitizer,antioxidants,probiotics,and lipid-lowering drugs.However,it is still unknown whether these methods can effectively prevent NAFLD-related HCC.This article reviews recent advances in the prevalence,pathogenesis,prevention,monitoring,and screening of NAFLD-related HCC.
作者
桂文芳
朱清静
杨玲
GUI Wenfang;ZHU Qingjing;YANG Ling(Department of Gastroenterology,Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430022,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2018年第12期2693-2697,共5页
Journal of Clinical Hepatology
基金
国家自然科学基金(81570530
81370550
30500658)
武汉卫生和计划生育委员会科研课题(WXD18D30)
关键词
非酒精性脂肪性肝病
肝肿瘤
综述
nonalcoholic fatty liver disease
liver neoplasms
review
作者简介
桂文芳(1992-),女,主要从事非酒精性脂肪性肝病和肝癌的基础与临床研究;通信作者:杨玲,电子信箱:hepayang@163.com。
