摘要
目的探讨聚焦超声联合竹红菌素软膏治疗对外阴上皮非瘤样病变组织P16、CD34的影响。方法选取2010年12月-2015年12月在衡水市人民医院进行治疗的80例外阴上皮非瘤样病变(NNED)患者为研究对象。其中,2013年12月以前入院的40例患者作为对照组,选择与其状况相似的2013年12月以后入院的40例患者作为观察组。对照组患者接受聚焦超声治疗,观察组患者接受聚焦超声联合竹红菌素治疗。比较两组患者治疗效果和治疗前后病变组织P16、CD34水平。结果治疗后两组患者外阴瘙痒评分、皮肤弹性评分和外阴白色病变面积均变小(P<0.05),观察组患者外阴瘙痒评分、皮肤弹性评分和外阴白色病变面积小于对照组(均P<0.05)。治疗后两组患者外阴组织P16蛋白水平均上升(P<0.05),但观察组患者治疗后P16水平较对照组更高(P <0.05),CD34蛋白水平下降(P <0.05),但观察组患者治疗后CD34蛋白水平更低(P <0.05)。结论聚焦超声联合竹红菌素软膏治疗NNED疗效好,能增加病变组织中P16蛋白含量,降低CD34蛋白含量,提示NNED的发生发展可能与细胞周期失调和微循环障碍有关。
Objective To explore therapeutic effect of focused ultrasound combined with Hypocrellins in patients with non-neoplastic intraepithelial lesions of vulva.Methods Totally 80 cases of non-epithelial tumor like lesions of epithelium were admitted in our hospital from December 2010 to December 2015.All patients received focused ultrasound treatment as standard treatment.Patients in observation group received additional treatment of Hypocrellins.Levels of P16 and CD34 in tissues were measured.Results Treatments induced decreased levels of scores of vulvar pruritus,skin elasticity score and area of white lesions of vulva in the two groups;additional treatment of Hypocrellins in observation group induced more significant improvement when compared with control group(P<0.05).All patients experienced increased levels of P16 protein and decreased levels of CD34 protein compared with those prior to any treatments.Still,treatment with Hypocrellins induced dramatical increase of P16 and decrease of CD34 compared with control group.Conclusions Focused ultrasound combined with Hypocrellins exerts promising therapeutic effect in treatment of NNED through manipulating cell cycle and microcirculation.
作者
张宪军
陈志红
李明
李桂芬
宋永祯
Xian-jun Zhang;Zhi-hong Chen;Ming Li;Gui-fang Li;Yong-zhen Song(Department of Gynecology,People’s Hospital of Hengshui City,Hengshui,Hebei 053000,China;Internal Medicine,People’s Hospital of Hengshui City,Hengshui,Hebei 053000,China)
出处
《中国现代医学杂志》
CAS
2018年第33期71-75,共5页
China Journal of Modern Medicine
基金
河北省衡水市科技计划项目(No:15003)
关键词
聚焦超声
竹红菌素软膏
外阴上皮内非瘤样病变
focused ultrasound
Hypocrellins
non-neoplastic intraepithelial lesions of vulva
