摘要
目的:构建一种新型支架材料(鹿角粉/PVA支架),并与n-HA/PVA支架对比,通过检测其理化、生物性能,评价并探讨其作为骨组织工程支架的可行性。方法:利用3D打印技术,分别制备出鹿角粉/PVA支架、n-HA/PVA支架,进行孔隙率、孔径、吸水率、压缩力学性能及生物相容性的检测。结果:两组支架孔隙率比较无差别,鹿角粉/PVA孔径大于n-HA/PVA支架(P=0.004);在不同时间点上,n-HA/PVA支架的吸水率大于鹿角粉/PVA支架,但鹿角粉/PVA支架持续吸水的时间较长;两组支架的抗压缩性能无差别(P=0.243),但韧性较n-HA/PVA支架好;鹿角粉/PVA支架细胞相容性优于n-HA/PVA支架。结论:鹿角粉/PVA支架具有良好的机械力学性能及细胞相容性,可作为异种骨支架材料研究的新方向。
Objective:A new scaffold material(antler powder/PVA scaffold)was constructed,and compared with n-HA/PVA scaffold.By testing its physicochemical and biological properties,its feasibility as a scaffold for bone tissue engineering was evaluated and explored.Methods:The antler powder/PVA scaffolds and n-HA/PVA scaffolds were respectively prepared by 3D printing technology to test the porosity,pore size,water absorption,compressive mechanical properties,and biocompatibility.Results:There was no difference in the porosity of two groups,and the pore sizes of antler powder/PVA scaffold were larger than those of n-HA/PVA scaffolds(P=0.004).At different time points,the water absorption of the n-HA/PVA scaffolds was greater than that of the antler powder/PVA scaffolds.However,the antler powder/PVA scaffolds had longer duration of water absorption.The compression resistance of two groups was not different(P=0.243).However,the toughness of antler power/PVA scaffold was better than that of n-HA/PVA scaffolds,and the cell compatibility was the same.Conclusion:Antler powder/PVA scaffolds have good mechanical properties and cell compatibilities,which can be used as a new direction to study the xenogeneic scaffolds.
作者
赵小琦
丁刘闯
韩祥祯
李俊杰
周琦琪
宋艳艳
何惠宇
ZHAO Xiao-qi;DING Liu-chuang;HAN Xiang-zhen;LI Jun-jie;ZHOU Qi-qi;SONG Yan-yan;HE Hui-yu(Department of Prosthodontics,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,China)
出处
《口腔医学研究》
CAS
北大核心
2018年第9期1011-1015,共5页
Journal of Oral Science Research
基金
国家自然科学基金(编号:81660177)
作者简介
赵小琦(1992~),女,新疆库尔勒人,硕士在读,主要研究口腔修复学及组织工程研究;通讯作者,何惠宇,E-mail:hehuiyu01@126.com
