摘要
目的:探讨参麦注射液联合利奈唑胺治疗儿童重症肺炎临床疗效及对炎性因子的影响。方法:收集100例儿童重症肺炎患者为研究对象,按照随机数字表法分为观察组和对照组,每组各50例。对照组给予利奈唑胺治疗,观察组在对照组基础上增加参麦注射液治疗,两组患者均连续治疗14d。治疗结束后比较两组患者临床效果以及不良反应发生情况。比较分析治疗前后两组患者血清炎性因子(IL-6、IL-8、CRP、TNF-α)水平变化情况。结果:观察组总有效率为92%,对照组为72%,两组比较具有统计学差异(P<0.05)。观察组咳嗽、发热、呼吸、心律以及肺部啰音等体征改善时间均显著低于对照组(P<0.05)。治疗前两组患者血清炎性因子水平比较无统计学差异(P>0.05),治疗后两组患者IL-6、IL-8、CRP以及TNF-α水平显著下降(P<0.05),且观察组IL-6、IL-8、CRP以及TNF-α水平均显著低于对照组(P<0.05)。观察组不良反应发生率为10%,显著低于对照组的28%。结论:参麦注射液联合利奈唑胺治疗儿童重症肺炎临床效果较好,症状改善明显,不良反应发生率低,并减轻患儿炎症反应,有利于患儿的恢复。
Objective:To investigate the clinical efficacy of Shenmai injection combined with linezolid in the treatment of severe pneumonia in children and its influence on inflammatory factors.Methods:A total of 100 children with severe pneumonia who were admitted to our hospital were collected and divided into observation group and control group according to the random number table method.There were 50 cases in each group.The control group received linezolid treatment.The observation group increased Shenmai injection on the basis of the control group.Both groups were treated for 14 days.After treatment,the clinical effects and adverse reactions of the two groups were compared.The levels of serum inflammatory factors(IL-6,IL-8,CRP,TNF-α)in the two groups before and after treatment were compared and analyzed.Results:The total effective rate was 92%in the observation group and 72%in the control group.There was significant difference between the two groups(P<0.05).The time of improvement of cough,fever,respiration,heart rhythm,and pulmonary rales in the observation group was significantly lower than that in the control group(P<0.05).Before treatment,there was no significant difference in serum inflammatory factors between the two groups(P>0.05).After treatment,IL-6,IL-8,CRP,and TNF-αlevels were significantly decreased in the two groups(P<0.05).The levels of IL-6,IL-8,CRP and TNF-αin the observation group were significantly lower than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was 10%,which was significantly lower than the control group 28%.Conclusion:Shenmai injection combined with linezolid has good clinical efficacy in the treatment of severe pneumonia in children.The clinical symptoms are obviously improved,the incidence of adverse reactions is low,and the inflammatory reaction in children is alleviated,which is beneficial to the recovery of children
作者
方柯南
Fang Kenan(Luoyang Women’s and Children’s Medical Care Center in Henan Province(Luoyang 471000))
出处
《陕西中医》
2018年第9期1187-1190,共4页
Shaanxi Journal of Traditional Chinese Medicine
关键词
肺炎/中西医结合疗法
儿童
@参麦注射液
Pneumonia/integrated
Chinese traditional and western medicine therapy
Children
@Shenmai injection
