摘要
目的：探讨利奈唑胺与替考拉宁治疗高龄患者院内重症耐甲氧西林金黄色葡萄球菌（MRSA）感染的疗效及安全性。方法：收集高龄男性重症MRSA感染患者临床资料97例,根据使用药物分为利奈唑胺组（42例）和替考拉宁组（55例）。利奈唑胺组给予利奈唑胺600 mg,ivgtt,bid;替考拉宁组给予替考拉宁400 mg,ivgtt,qd,治疗首日剂量加倍。两组疗程均为7～21 d。观察两组患者治疗后临床有效率、细菌清除率、不良反应等。结果：细菌清除率替考拉宁组为52.6%,利奈唑胺组为73.5%,利奈唑胺组细菌清除率显著高于替考拉宁组,差异有统计学意义（χ^2=12.57,P=0.034）;临床有效率,利奈唑胺组为78.6%,替考拉宁组为58.2%,利奈唑胺组显著高于替考拉宁组,差异有统计学意义（χ^2=9.56,P=0.018）。替考拉宁组和利奈唑胺组患者治疗14 d后急性生理及慢性健康评分Ⅱ（APACHEⅡ）评分分别为（14.56±3.04）、（10.29±4.84）分,利奈唑胺组低于替考拉宁组,差异有统计学意义（t=10.97,P=0.014）;利奈唑胺组患者不良反应发生率为11.9%,替考拉宁组为20.0%,差异无统计学意义（χ^2=1.13,P=0.287）。结论：利奈唑胺治疗高龄患者院内重症MRSA感染疗效显著优于替考拉宁,安全性较好。
OBJECTIVE：To investigate therapeutic efficacy and safety of linezolid and teicoplanin in the elderly patients with severe MRSA infection. METHODS：97 elderly patients with severe MRSA infection were collected and divided into linezolid group（42 patients） and teicoplanin group（55 patients）. Linezolid group was given linezolid 600 mg intravenously,bid;teicoplanin group was given teicoplanin 400 mg intravenously,qd,double dose for the first day. Treatment course lasted for 7-21 d. Clinical effective rate,bacterium clearance rate and ADR were compared between 2 groups after treatment. RESULTS：The bacterium clearance rate of teicoplanin group was 52.6%,and that of linezolid group was 73.5%;the linezolid group was significantly higher than the teicoplanin group,with statistical significance（χ^2=12.57,P=0.034）. Clinical effective rate was 78.6% in linezolid group and 58.2% in teicoplanin group;the linezolid group was significantly higher than the teicoplanin group,with statistical significance（χ^2=9.56,P=0.018）. After 14 days of treatment,APACHEⅡ score of teicoplanin group and linezolid group were（14.56±3.04）and（10.29±4.84）,respectively;the teicoplanin group was lower than the linezolid group,with statistical significance（t=10.97,P=0.014）. The incidence of ADR was 11.9% in linezolid group and 20.0% in teicoplanin group,with statistical significance（χ^2=1.13,P=0.287）. CONCLUSIONS：Linezolid has superior curative effect to teicoplanin in the treatment of severe MRSA infection in elderly patients with good safety.
出处
《中国药房》
CAS
北大核心
2015年第29期4140-4142,共3页
China Pharmacy
作者简介
主治医师，博士。研究方向：老年心血管。电话：021-25078999。E—mail：jennysh78@163．com
