摘要
果胶作为高等植物初生细胞壁和中胞层的重要组成成分,是通过α-1,4糖苷键连接而成的D-半乳糖醛酸多聚物。天然果胶作为膳食纤维的一种,可被肠道微生物分解和发酵利用,有利于降低结肠癌的风险。但为了提高生物活性和生物利用度,天然果胶常被改性成低分子量和低酯化度的果胶片段。有报道显示相当一部分改性果胶能够通过干预癌细胞中的关键靶蛋白(半乳糖凝集素-3)被配体识别从而实现抗瘤效应。基于果胶的分子结构,主要综述近几年关于天然果胶和改性果胶的抗肿瘤活性和机制的研究及其在癌症治疗中的相关应用,为今后的相关深入研究提供了一定的参考依据。
Pectin is a major component of the primary cellular walls and middle lamella in plant tissues,which contains large amount of poly D-galacturonic acid bonded viaα-1,4-glycosidic acid linkage.According to the different sources and extraction methods,the backbone structure of pectin consists of three types of galacturonic acids including homogalacturonan(HG),rhammogalacturonan-Ⅰ(RG-Ⅰ)and rhammogalacturonan-Ⅱ(RG-Ⅱ).At present,extensive studies of pectin antitumor activities have been focused on colon cancer and its direct or indirect roles on probiotics in intestine.As a dietary fiber,natural pectin can be degraded and fermented by colonic microbes,which is helpful to reduce the risk of colon cancer.However,to enhance its bioavailability and bioactivity,pectin is modified into bioavailable modified pectin fragments with low molecular mass and degree of esterification.Galectin-3(Gal-3),a member of the galectin family,binds with its glycol-ligands on the cell surface,and participates in multiple biological processes including tumor angiogenesis.It is reported that the antitumor activity of quite a number of modified pectin fragments arise from intervention in ligand recognition by Gal-3,a key target in cancer cells.Basing on the molecular structure of pectin,this paper mainly reviewed the results of recent investigations on antitumor activities and mechanisms of natural pectin and modified pectin as well as applications of the pectin in cancer therapy,which could provide certain references for further researches in the future.
作者
曾祥权
奚宇
赵珂
姜微波
ZENG Xiangquan;XI Yu;ZHAO Ke;JIANG Weibo(College of Food Science and Nutritional Engineering,China Agricultural University,Beijing 100083,China)
出处
《河南工业大学学报（自然科学版）》
CAS
北大核心
2018年第2期122-130,共9页
Journal of Henan University of Technology：Natural Science Edition
基金
国家重点基础研究发展规划项目(973计划)(2013CB127106)
作者简介
曾祥权(1994一),男,江西赣州人,博士研究生,研究方向为农产品加工及贮藏工程。;通信作者:姜微波,教授,E-mail:jwb@cau.edu.cn。
