摘要
目的探讨衰弱对老年心力衰竭患者预后的影响。方法纳入2014年1月至2016年6月住院的老年心力衰竭患者371例,对一般情况、病史资料等进行调查,完成Fried衰弱量表评分,记录随访临床终点事件包括再入院次数及死亡人数1年。结果 371例研究对象中,衰弱发生率为21.3%。多因素Logistic回归分析显示高龄、脑血管病、肾功能不全、NYHA分级为老年心力衰竭患者发生衰弱的独立危险因素(均P<0.05)。Cox回归分析显示1年内老年心力衰竭伴衰弱的患者发生再入院或死亡的终点事件是非衰弱患者1.54(1.02～2.31)倍(P=0.038)。Fried量表中步速测试阳性患者发生再入院或死亡的终点事件增加了1.52(1.07～2.15)倍(P=0.019)。结论衰弱增加老年心力衰竭患者的临床终点事件。
Objective To investigate the effect of frailty on the prognosis of elderly patients with chronic heart failure.Methods A total of 371 elderly patients with chronic heart failure in our hospital from January,2014 to June,2015 were enrolled in the study.The demographic characteristics and medical record data were collected.All patients received frailty assessment with Fried criteria.The number of re-admission times and the number of deaths were recorded for 1 year.Result The prevalence rate of frailty was 21.3%in 371 patients.Multivariate logistic regression analysis indicated that advanced age,cerebrovascular disease,renal insufficiency and NYHA classification were significantly associated with frailty(all P<0.05).COX regression analysis showed that at the end of the follow-up,frailty was associated with a 1.54-fold increase in 1-year re-admission or all-cause mortality risk(95%CI:1.02,2.31,P=0.038);gait speed as an individual components of frailty remained as-sociated with a 1.52-fold increase in 1-year cardiac re-admission or all-cause mortality risk(95%CI:1.07,2.15,P=0.019).Conclusion Frailty may increase 1-year re-admission or all-cause mortality risk in elderly patients with chronic heart failure.
作者
卓裕丰
段跃兴
郑栋
伍金雷
程颖
黄冰生
林桂雄
吴钰燕
冯燕玲
张鹏
ZHUO Yufeng;DUAN Yuexing;ZHENG Dong;WU Jinlei;CHENG Ying;HUANG Bingsheng;LIN Guixiong;WU Yuyan;FENG Yanling;ZHANG Peng(Department of Cardiology,Hexian Memorial Hospital of Panyu District,Guangzhou 511400,China)
出处
《实用医学杂志》
CAS
北大核心
2018年第15期2514-2517,共4页
The Journal of Practical Medicine
基金
广东省科技厅资助项目(编号:2016A020215014)
广州市番禺区科技局科研项目资金资助(编号:2014-Z03-19)
关键词
老年
心力衰竭
衰弱
预后
the aged
chronic heart failure
frailty
prognosis
