摘要
目的:探讨银杏叶提取物片联合百乐眠胶囊治疗特发性耳鸣伴失眠患者的临床效果。方法:特发性耳鸣伴失眠患者82例,随机分为两组,每组各41例。对照组给予银杏叶提取物片口服,40mg,3次/d,观察组在对照组的基础上给予百乐眠胶囊口服,4粒/次,2次/d,以耳鸣残障量表(THI),匹兹堡睡眠质量指数(PSQI)评价患者的疗效。结果:治疗4周后,两组患者THI和PSQI评分较治疗前均有明显改善(P<0.05),两组间有统计学差异(P<0.05),其中观察组THI和PSQI改善了31.7%和33.2%,对照组THI和PSQI改善了17.1%和8.5%,提示观察组与对照组相比疗效更加明显。结论:银杏叶提取物片联合百乐眠胶囊对比传统单一药物对特发性耳鸣具有更好的疗效,同时也可以明显改善失眠等并发症。
Objective:To observe the efficacy of Bailemian Capsule combined with Extract of Ginkgo Biloba Leaves tablets in treating subjective idiopathic tinnitus with insomnia.Methods:82 cases of subjective idiopathic tinnitus with insomnia patients were randomly divided into experimental group(n=41)and control group(n=41).The experimental group was treated with oral Bailemian capsule combined with extract of ginkgo biloba leaves tablets,and the control group was given oral extract of ginkgo biloba leaves tablets.The tinnitus handicap inventory(THI)and Pittsburgh sleep quality index(PSQI)before and after treatment were compared between two groups before and after treatment.Results:Before treatment the THI of experimental group and control group were 45.78±8.77 and 45.56±8.05 respectively,after 4 weeks the THI of experimental group and control group were 31.29±5.50 and 37.76±6.66 respectively,which were both lower than before(P<0.05),while the THI of experimental group was much lower than control group,there was significant difference between the two groups after treatment(P<0.05).Before treatment the PQSI of experimental group and control group were 15.44±2.71 and 15.39±2.57 respectively,after 4 weeks the PQSI of experimental group and control group were 10.37±2.52 and 14.24±2.13 respectively,which were both lower than before(P<0.05),while the PQSI of experimental group was much lower than control group,there was significant difference between the two groups after treatment(P<0.05).The incidence of adverse reactions of experimental group and control group were 9.8%and 7.3%respectively,there was no significant difference between the two groups.Conclusion:Bailemian capsule combined with extract of ginkgo biloba leaves tablets is effective in the treatment of subjective idiopathic tinnitus with insomnia,which is worthy of clinical promotion.
作者
梁昆
常会敏
岳波
查定军
邱建华
陈福权
Liang Kun;Chang Huimin;Yue Bo(Department of Otolaryngology Head and Neck Surgery,Xijing Hospital Affiliated to Air Force Medical University(Xi’an 710032))
出处
《陕西医学杂志》
CAS
2018年第8期1053-1055,共3页
Shaanxi Medical Journal
基金
国家自然科学基金资助面上项目(81670925)
作者简介
通讯作者,陈福权。
