摘要
目的探析红细胞参数在孕检人员筛查地中海贫血的应用价值。方法选取2015年6月~2017年6月到我院接受孕检的300例孕检人员为主要研究对象,采用全自动血液分析仪对孕检人员的红细胞参数进行测定,分析其地中海贫血基因,对孕检人员的各项红细胞参数检测结果以及最终的筛查诊断结果进行回顾性分析。结果 300例孕检人员中,地中海贫血检测阳性165例(观察组),地中海贫血检测阴性135例(对照组)。观察组研究对象的红细胞平均体积(MCV)、平均红细胞血红蛋白量(MCH)均明显低于对照组,观察组的红细胞分布宽度变异系数(RDW-CV)高于对照组,两组之间的红细胞参数检测值比较差异有统计学意义(P<0.05)。红细胞参数检测和基因诊断在地中海贫血与非地中海贫血研究对象上的诊断准确率比较差异无统计学意义(P>0.05)。结论在孕检时采用检测红细胞参数的方式筛查地中海贫血,是一种经济、有效的筛查方法,可根据各项红细胞参数值判断是否患有地中海贫血,提升孕检效率。
Objective Application value of erythrocyte parameters in screening for thalassemia among pregnant examiners.Methods From June 2015 to June 2017,300 pregnant people who received pregnancy examination in our hospital were selected as the main research objects.The parameters of erythrocyte were measured by automatic blood analyzer,and the gene of thalassemia was analyzed.The results of erythrocyte parameters and final screening diagnosis were analyzed retrospectively.Results Among 300 pregnant women,165 cases were positive for thalassemia(observation group),135 cases were negative for thalassemia(control group).The mean corpuscular volume(MCV)and mean corpuscular hemoglobin(MCHM)in the observation group were significantly lower than those in the control group,and the RDW-CVC of the RBC distribution width in the observation group was higher than that in the control group.The difference of erythrocyte parameters between the two groups was statistically significant.Conclusion It is an economical and effective method to screen thalassemia by detecting erythrocyte parameters during pregnancy examination.It can be used to judge whether there is thalassemia or not according to the values of erythrocyte parameters and to improve the efficiency of pregnancy examination.
作者
吕健忠
陈伯廷
关锐梨
LV Jianzhong;CHEN Boting;GUAN Ruili(Inspection Department,Maternal and Child Health Care Family Planning Service Center,Kaiping 529300,China)
出处
《中国医药科学》
2018年第7期132-134,共3页
China Medicine And Pharmacy
关键词
红细胞参数
孕检
筛查
地中海贫血
Erythrocyte parameters
Pregnancy test
Screening
Thalassemia
