摘要
目的探究妊娠中期孕妇产前筛查及随访的意义。方法选取南阳市卧龙区计划生育宣传技术指导站2014年1月~2016年12月期间收治的妊娠中期孕妇1500例,收集所有孕妇体重、孕周、年龄、妊娠史等临床资料,进行胎儿超声检查并对胎龄进行评估。筛查胎儿解剖结构的异常。同时以时间分辨荧光免疫分析仪对所采集血清样本进行测定,将检测结果输入Life-Cycle 3.2软件,并结合体重、孕周、年龄等数值,计算出开放性神经缺陷、爱德华氏综合征及唐氏综合征风险值。统计筛查及随访结果,比较高风险孕妇与低风险孕妇不良妊娠结局。结果1500例孕妇中,高风险孕妇106例,占7.07%,低风险孕妇304例,占20.27%,其中开放性神经缺陷、爱德华氏综合征、唐氏综合征高风险人数分别为4例、15例、87例,有68例高风险孕妇自愿接受羊膜腔染色体核型分析,羊水穿刺率为64.15%;有效随访1102例,有效随访率为73.47%,失访主要原因包括不配合随访、号码错误、关机、无法接通、空号或停机、无人接听等;高风险孕妇不良妊娠结局总发生率高于低风险孕妇,差异有统计学意义(P<0.05)。结论妊娠中期血清检测及超声检查等产前筛查对开放性神经缺陷、爱德华氏综合征及唐氏综合征高风险孕妇有一定预测价值,临床中应对此类疾病高风险孕妇积极采取有效措施进行干预,以降低不良妊娠结局发生率,同时应做好产前筛查后随访工作。
Objective To investigate the significance of the prenatal screening on females with mid trimester of pregnancy.Methods A total of 1500 cases of women in the middle trimester of pregnancy from January 2014 to December 2016 in our hospital were selected.All pregnant women s weight,pregnancy,age,pregnancy history and other clinical data were collected.Fetal ultrasound examination was performed and evaluation of fetal age was made.The abnormality of fetal anatomical structure was screened.The number of umbilical arteries was detected.At the same time,all collection of serum samples was determined by the time-resolved fluoroimmunoassay instrument.The detection result would be input into Life-Cycle 3.2 software,and combined with the value of weight,gestational age to calculate the risk values of open nerve defects,Edward s syndrome and Down s syndrome.The results of screening and follow-up were statistically recorded.The adverse pregnancy outcomes between high risk pregnant women and low risk pregnant women were compared.Results Among the 1500 pregnant women,there were 106 cases of high risk pregnant women,accounting for 7.07%,and 304 cases of low risk pregnant women,accounting for 20.27%.The numbers of high risk persons of open nerve defects,Edward s syndrome and Down s syndrome are 4cases,15cases and 87 cases respectively.There were 68 cases of high risk pregnant women voluntarily accepting the karyotype analysis of amniotic cavity,and the rate of amniocentesis was 64.15%.A total of 1102 cases were effectively followed up,and the effective rate was 73.47%.The main reasons of ineffective follow-up included the incompatibility with follow-up,error number,shutdown,unable to connect,empty or stop,and no answer.The total incidence of undesirable pregnancy outcome in high risk pregnant women was higher than that of low risk pregnant women(P<0.05).Conclusion Prenatal screening like serum and ultrasound examination and others in mid trimester of pregnancy has a certain predictive value for high risk pregnant women with open neural defects,Edward s syndrome and Down s syndrome.In order to reduce the incidence of adverse pregnancy outcomes,effective measures should be taken to intervene the high risk pregnant women of this kind of disease.The follow-up work of prenatal screening should be done at the same time.
作者
牛牧
季晓丽
NIU Mu;JI Xiao-li(Department of Ultrasonography,Family Planning Publicity Technical Guidance Station in Wolong District of Nanyang,Nanyang,Henan,473000,China;Department of Clinical Laboratory,Family Planning Publicity Technical Guidance Station in Wolong District of Nanyang,Nanyang,Henan,473000,China)
出处
《临床研究》
2018年第5期3-5,共3页
Clinical Research
关键词
妊娠中期
产前筛查
唐氏综合征
不良妊娠结局
mid trimester of pregnancy
prenatal screening
down s syndrome
adverse pregnancy outcome
作者简介
牛牧(1978-),女,汉族,河南南阳人,主治医师,本科。研究方向:超声检查。
