摘要
目的观察不同剂量甲泼尼龙对百草枯(Paraquat)中毒治疗的影响。方法 89例百草枯中毒患者根据甲泼尼龙用量分为小剂量组与大剂量组,比较不同剂量甲波尼龙对百草枯中毒患者的治疗情况及预后。结果治疗2周后,小剂量组丙氨酸氨基转移酶(ALT)(89±17)U/L、血肌酐(Cr)(142±28)μmol/L、C反应蛋白(CRP)(22±6)mg/L的升高程度小于大剂量组的(110±28)U/L、(218±22)μmol/L、(33±8)mg/L,差异有统计学意义(P<0.05);动脉血氧分压(Pa O2)小剂量组的好转情况优于大剂量组,差异有统计学意义(P<0.05);住院时间小剂量组短于大剂量组及肺纤维化开始时间晚于大剂量组,差异有统计学意义(P<0.05);生存率小剂量组高于大剂量组,差异有统计学意义(P<0.05)。结论小剂量甲泼尼龙可有效增加百草枯中毒治疗效果及生存率,减少或延缓肺纤维化。
Objective To summary the experience of different doses of Methylprednisolone in the treatment of Paraquat poisoning.Methods Analyzing the clinical data of 89 patients with Paraquat poisoning,and summing the treatment and prognosis.Results 89 patients were treated in small dose group and high-dose groups according to the amount of methylprednisolone,after two weeks of treatment,in low-dose group,ALT,Cr,CPR level increased significantly less than the high-dose group(P<0.05),and small dose group hospitalization and pulmonary fibrosis was significantly less than the start time of the high dose group(P<0.05),and the survival rate was higher than the high dose group.The difference was statistical significance(P<0.05).Conclusion Small doses of methylprednisolone can effectively increase the treatment effect and the survival of paraquat poisoning,and reduce or delay pulmonary fibrosis.
作者
彭飞
杨丛和
PENG Fei;YANG Cong-he(Emergency Department,The Central Hospital of Zhumadian,Zhumadian Henan 463000,China)
关键词
百草枯中毒
甲泼尼龙
治疗
paraquat poisoning
methylprednisolone
treatment
作者简介
彭飞(1985-),男,河南省新蔡县人,硕士,医师,从事急诊科临床工作。
