摘要
足细胞是肾小球滤过屏障的重要组成部分,其数量减少或功能障碍将导致肾小球滤过功能损伤和相关肾脏疾病的发生。足细胞为不可再生性细胞,其数量和功能在一定程度上取决于其正常发育。已发表的文献和本实验室的研究工作表明,遗传或不良宫内环境等原因所致的足细胞发育不良,可能导致成年后肾小球滤过功能障碍,并成为某些胎源性肾脏疾病发生或易感的病因之一,而表观遗传学机制可能参与介导足细胞发育过程中某些关键基因的表达异常。本文对足细胞结构功能和正常发育、足细胞发育异常的病因和机制、以及足细胞发育异常所致的肾脏疾病等几方面进行综述,以期对发育源性足细胞相关肾脏疾病的诊断与治疗提供借鉴与参考。
Podocyte is one of the main components of glomerular filtration barrier in the kidney;the loss or dysfunction of podocyte could impair the functions of glomerular filtration barrier,leading to development of various renal diseases.Podocyte is a terminally differentiated cell,and thus does not possess any proliferative properties.Accordingly,its number and contribution to renal function are initially determined by its normal development.Information from the literature and results of our research indicate that genetic factors or prenatal adverse environment could cause developmental retardation of podocytes,thereby suggesting the potential fetal developmental origin(s)of kidney diseases,and involvement of epigenetic mechanisms in the regulation of key genes in podocyte development.In this review,we provide a brief overview on the podocyte normal development;discussion on the potential pathogenic mechanisms for developmental disorders of podocytes;as well as renal diseases associated with podocyte developmental retardation.We aim to provide some insights in articulating the strategies for diagnosis and treatments of renal diseases associated with podocyte developmental abnormalities.
作者
朱亚男
敖英
李斌
万阳
汪晖
陈雁
Yanan Zhu;Ying Ao;Bin Li;Yang Wan;Hui Wang(Hubei Provincial Key Laboratory of Developmentally Originated Diseases, Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan 430071, China;Department of Orthopedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China)
出处
《遗传》
CAS
CSCD
北大核心
2018年第2期116-125,共10页
Hereditas（Beijing)
基金
国家自然科学基金项目(编号:81220108026, 81430089, 81001466),湖北省卫计委项目(编号:WJ2017M002)和湖北省自然科学基金项目(编号:2017CFB649)资助
关键词
足细胞发育
肾脏疾病
遗传因素
孕期不良环境
表观遗传
podocyte development
renal diseases
genetic factors
prenatal adverse environment
epigenetics
作者简介
朱亚男,硕士研究生,专业方向:药物毒理学。E-mail:happy_zhuyn@163.com;通讯作者: 敖英,博士,副教授,硕士生导师,专业方向:肾病的发育起源及药物防治,肾脏发育毒理。E-mail:yingao@whu.edu.cn
