摘要
目的观察参附养心汤治疗老年阳虚水泛型慢性心力衰竭的临床效果。方法将老年阳虚水泛型慢性心力衰竭患者92例随机分为观察组和对照组,每组46例。对照组采用西医常规治疗,观察组在对照组治疗方法基础上给予参附养心汤治疗。治疗4周后,对两组患者临床疗效、脑钠肽(BNP)、6 min步行距离、心功能指标[左心室舒张末期容积(LVEDV)、收缩末期容积(LVESV)、左心室射血分数(LVEF)]及细胞炎性因子[白细胞介素-6(IL-6)、肿瘤坏死因子(TNF-α)、超敏C-反应蛋白(hs-CRP)]进行比较。结果治疗4周后,观察组总有效率为89.1%,显著高于对照组71.7%,差异具有统计学意义(P<0.05);观察组的BNP水平显著低于对照组,而6 min步行距离显著高于对照组,差异具有统计学意义(P<0.05);观察组的LVEDV、LVESV均显著低于对照组,而LVEF高于对照组,差异具有统计学意义(P<0.05);观察组的血清hs-CRP、IL-6及TNF-α水平均显著低于对照组,差异具有统计学意义(P<0.05)。结论参附养心汤能显著改善老年阳虚水泛型慢性心力衰竭患者的心功能指标,降低BNP水平,减轻炎症反应,提高运动耐量,疗效显著。
Objective To observe the clinical effect of Shenfu Yangxin decoction in the treatment of in elderly patients with chronic heart failure of heart Yang deficiency and water overflow syndromes.Methods92cases of chronic heart failure patients with heart Yang deficiency and water overflow syndromes were randomly divided into the observation group and the control group,46cases in each group.The control group was treated with routine Western medicine.Based on this,the observation group was treated with Shenfu Yangxin decoction.Afterweeks of treatment,the clinical efficacy,the brain natriuretic peptide(BNP),6min walking distance,left ventricular function indexes(LVEDV,LVESV,LVEF)and inflammatory cytokines(IL-6,TNF-α,hs-CRP)were compared.Results After4weeks of treatment,the total effective rate of the observation group after treatment was91.3%,which was significantly higher than that of the control group(71.7%),and the difference was statistically significant(P<0.05).The level of BNP of the observation group was significantly lower than that of the control group,while the6min walking distance was significantly higher than that of the control group,the difference was statistically significant(P<0.05).The LVEDV,LVESV index of the observation group were significantly lower than those of the control group,while the LVEF index of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).The serum hs-CRP,IL-6and TNF-levels in the observation group were significantly lower than those in the control group,the difference was statistically significant(P<0.05).Conclusion The application of Shenfu Yangxin decoction can significantly improve the heart function index in chronic heart failure elderly patients with heart Yang deficiency and water overflow syndromes,reduce the BNP level and inflammatory reaction,and improve the exercise tolerance,which is remarkable.
作者
李娟
尹胜
李定祥
LI Juan;YIN Sheng;LI Dingxiang(Hengyang Traditional Chinese Medicine Hospital Affiliated to Hunan University of Chinese Medicine, Hunan, Hengyang 421001, China;Hunan University of Chinese Medicine, Changsha, Hunan 410208, China)
出处
《湖南中医药大学学报》
CAS
2017年第12期1386-1390,共5页
Journal of Hunan University of Chinese Medicine
基金
湖南省自然科学基金项目(14JJ2113)
关键词
老年慢性心力衰竭
阴虚水泛
参附养心汤
心功能
脑钠肽
炎性因子
senile chronic heart failure
Yang deficiency and water overflow
Shenfu Yangxin decoction
heart function
brain natriuretic peptide
inflammatory factors
作者简介
李 娟,女,副主任医师,研究方向:心脑血管疾病研究。;〔通讯作者〕李定祥,男,教授,硕士研究生导师,E-mail:ldxlzy@HOTMAIL.com。
