摘要
目的探讨支气管扩张患者BMI与肺功能及疾病严重程度的相关性。方法将85例支气管扩张住院患者分为低BMI组(BMI<18.5 kg/m^2,n=14)、正常BM I组(18.5 kg/m^2≤BMI≤25 kg/m^2,n=47)和高BM I组(BM I>25 kg/m^2,n=24)。比较3组患者血气分析结果、CRP水平、降钙素原(procalcitionin,PCT)及常规肺功能检测结果;分析患者BMI与FVC、IVC、DL_(CO)的相关性。结果低BMI组的体质量、Pa O_2、DL_(CO)、FVC、FEV1%pred、IRV低于正常BM I组(P<0.05)。低BM I组的体质量、Pa O_2、DL_(CO)、FVC、IRV、IVC低于高BMI组(P<0.05)。低BM I组的PCT高于正常BM I组和高BM I组(P<0.05)。将85例支气管扩张患者的BM I与FVC、IVC、DL_(CO)进行Pearson相关分析,并进行显著性检验,提示BM I与FVC、IVC、DL_(CO)呈正相关。结论低BMI组的DL_(CO)和FEV_1%pred减低更显著,炎症反应更严重。
ObjectiveTo investigate the correlation of body mass index(BMI)with lung function and disease severity in patients with bronchiectasis.MethodsEighty five patients with brochiectasis were divided into three groups according their BMI:normal BMI group(185kg/m2≤BMI≤25kg/m2,n=47),high BMI group(BMI>25kg/m2,n=24)and low BMI group(BMI<185kg/m2,n=14).The levels of blood glucose,C reacting protein(CRP),procalcitionin(PCT)and pulmonary function test were compared among three groups.The correlation of BMI with FVC,IVC and DLCO was analyzed.ResultsThe body mass,PaO2,DLCO,FVC,FEV1%pred and IRV of the low BMI group were lower than those of the normal BMI group.The body mass,PaO2,DLCO,FVC,IRV,IVC of the low BMI group were lower than those of high BMI group.PCTs levels in the low BMI group were higher than those in the normal BMI group and the high BMI group.Pearson correlation analysis showed that BMI positively correlated with FVC,IVC and DLCO.ConclusionThe lung function in brochiectasis patients with low BMI is significantly lower,and the inflammation is more severe and more active.
作者
韩志青
单锡峥
褚海青
HAN Zhi-qing;SHAN Xi-zheng;CHU Hai-qing(Dept, of Respiratory, Yangpu Hospital, Tongji Uniniversity, Shanghai 200090, China;Dept, of Respiratory, Pulmonary Hospital, Tongji University, Shanghai 200433, China)
出处
《同济大学学报（医学版）》
CAS
2017年第5期96-101,107,共7页
Journal of Tongji University(Medical Science)
基金
上海市科委医学引导项目(14411962900)
作者简介
韩志青(1969—),女,副主任医师,硕士.E-mail:13621679978@163.com;通信作者:诸海青.E-mail:chu_haiqing@126.com
