摘要
目的:通过小鼠实验探讨美藤果油改善记忆功能的作用。方法:72只雄性SPF级昆明小鼠随机分为空白组,模型组,美藤果油低、中、高剂量组(375.1、750.2、1 500.0 mg/(kg·d),以体质量计,下同)及深海鱼油组(1 500.0 mg/kg)。连续给药30 d后,进行避暗、跳台、Morris水迷宫实验。结果:美藤果油750.2、1 5 0 0.0 mg/(k g·d)剂量组能剂量依赖性地显著延长模型小鼠避暗和跳台实验的潜伏期,减少错误次数(P<0.05),而对Morris水迷宫测试中的潜伏期及游泳路程百分比无显著影响。结论:美藤果油在375.1~1 500.0 mg/(kg·d)的剂量范围内可能具有辅助改善小鼠记忆功能的作用。
Objective:To investigate the effect of sacha inchi oil on improving memory in mice.Methods:Totally72SPF male KM mice were randomly divided into control group,model group,sacha inchi oil low-medium-,high-dose groups(375.1,750.2and1500.0mg/(kg·d))and deep-sea fish oil group(1500.0mg/(kg·d)).The animals were intragastrically administered for30days.After the experimental period,step-through test,step-down test and Morris water maze test were carried out.Results:In the medium-and high-dose groups,sacha inchi oil could prolong the latency time and reduce the number of errors in step-through test and step-down test(P<0.05),but had no significant effect on the latency time or the percentage of swimming distance in Morris water maze.Conclusion:Sacha inchi oil may play an important role in memory improvement in mice at a dose from375.1to1500.0mg/(kg·d).
作者
司茹
郑梦思
邹莉波
SI Ru;ZHENG Mengsi;ZOU L(Life Science and Biopharmaceutics Academy, Shenyang Pharmaceutical University, Shenyang 110016, China)
出处
《食品科学》
EI
CAS
CSCD
北大核心
2017年第9期202-206,共5页
Food Science
作者简介
司茹（1989—），女，硕士研究生，主要从事神经药理学研究。E-mail：18802461676@163.com;通信作者：邹莉波（1959—），女，教授，博士，主要从事神经药理学研究。E-mail：libozou@163.com
