摘要
目的探讨围术期给予腹部手术患者高浓度吸氧治疗后患者临床相关指标的变化情况以及切口感染情况。方法选取2015年12月-2016年6月于医院行腹部手术患者444例为研究对象,随机分为试验组和对照组,各222例。试验组患者给予围术期高浓度吸氧干预,对照组给予常规干预。对两组患者炎症因子指标[白细胞介素-6(IL-6)、IL-8、IL-12、IL-18和肿瘤坏死因子-α(TNF-α)、T细胞亚群指标(CD3+CD4+,CD3+CD8+,CD4+CD45+和CD8+CD45+)]和切口感染发生率进行分析。结果试验组患者IL-6、IL-8、IL-12、IL-18和TNF-α分别为(66.32±32.21)ng/L、(67.23±43.30)ng/L、(96.24±35.23)ng/L、(185.34±48.11)ng/L和(16.58±6.46)ng/L低于对照组(P<0.05);试验组患者CD3+CD4+和CD3+CD8+分别为(699.27±166.24)细胞/μl和(415.33±173.25)细胞/μl高于对照组(P<0.05);试验组222例患者中切口感染9例,切口感染率为4.05%低于对照组的9.91%(22/222)(P=0.016)。结论围术期给予腹部手术患者高浓度吸氧干预能有效控制患者炎症因子水平,改善免疫功能指标,降低术后切口感染发生率,具有一定的临床价值。
OBJECTIVE To explore the changes of related clinical indexes of the abdominal surgery patients who were given perioperative inhalation of high concentration oxygen and analyze the incidence of incision infection.METHODS A total of444 patients who received abdominal surgery in the hospital from Dec 2015 to Jun 2016 were recruited as the study objects and randomly divided into the experimental group and the control group,with 222 cases in each group.The experimental group was given perioperative inhalation of high concentration oxygen,while the control group was given conventional intervention.The levels of inflammatory factors interleukin-6（IL-6）,IL-8,Il-12,IL-18 and tumor necrosis factor-α（TNF-α）,T lymphocyte subsets（CD3＋CD4＋,CD3＋CD8＋,CD4＋CD45＋and CD8＋CD45＋）and incidence of incision infection were observed and compared between the two groups of patients.RESULTS The levels of IL-6,IL-8,IL-12,IL-18 and TNF-αof the experimental group were respectively（66.32±32.21）ng/L,（67.23±43.30）ng/L,（96.24±35.23）ng/L,（185.34±48.11）ng/L and（16.58±6.46）ng/L,significantly lower than those of the control group（P〈0.05）.The levels of CD3＋CD4＋and CD3＋CD8＋of the experimental group were respectively（699.27±166.24）/μl and（415.33±173.25）/μl,significantly higher than those of the control group（P〈0.05）.The incidence rate of incision infection of the experimental group was 4.05%（9/222）,significantly lower than 9.91%（22/222）of the control group（P=0.016）.CONCLUSLONS The perioperative inhalation of high concentration oxygen may facilitate the effective control of the levels of inflammatory factors of the abdominal surgery patients,improve the immune function indexes and reduce the incidence of postoperative incision infection.It is has certain clinical value.
作者
张素梅
王军
谭梅
刘燕
ZHANG Su-mei;WANG Jun;TAN Mei;LIU Yan(The First Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou,Inner Mongolia 014010,China)
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2018年第21期3270-3273,共4页
Chinese Journal of Nosocomiology
基金
内蒙古自治区自然科学基金资助项目(N2016-2538)
关键词
围术期
高浓度吸氧
腹部手术
切口感染
Perioperative period
Inhalation of high concentration oxygen
Abdominal surgery
Incision infection
