摘要
自噬是一个高度保守的过程，可降解细胞中长寿命的蛋白质和细胞器。越来越多的证据表明，自噬途径的失调与。肾脏功能障碍以及老化的发病机制有关，肾脏微血管参与了许多生理过程，如调节血管舒张及收缩，增加血管渗透性，白细胞募集和抗血栓形成等。因此，内皮细胞功障碍可能导致肾功能不全，并可能促进慢性肾脏疾病和肾脏纤维化的进展。但目前关于内皮细胞自噬在肾脏疾病中的研究相对较少，鉴于内皮细胞功能障碍在肾脏疾病中的重要性，现就肾脏疾病中内皮细胞的自噬进行总结。
Autophagy is a highly conservative process that degrades long-lived proteins and organelles in cells. There are increasing evidences that the disorder of autophagic pathways is related to the pathogenesis of kidney dysfunction and aging. Renal microvasculature is involved in many physiological processes, such as regulating vascular dilatation, contraction, permeability, leukocyte recruitment, anti-thrombosis, etc. Therefore, endothelial dysfunction may lead to renal insufficiency and may promote the progression of chronic kidney disease （CKD） and kidney fibrosis. However, at present, there is relatively little research on endothelial cell autophagy in kidney diseases, and because of its importance in pathogenesis of various renal diseases, it is necessary to summarize the autophagy of endothelial ceils in kidney diseases.
作者
庞冉
段美丽
李昂
刘景峰
Pang Ran;Duan Meili;Li Ang;Liu Jingfeng(Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China;Beijing Ditan Hospital,Capital Medical University,Beijing 100015,China)
出处
《中国中西医结合急救杂志》
CAS
CSCD
北大核心
2018年第5期555-557,共3页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
基金
国家自然科学基金（81471849）
关键词
内皮细胞
自噬
肾脏疾病
Endothelial cell
Autophagy
Kidney disease
作者简介
通讯作者：段美丽，Email：beauty9659@hotmail．com
