摘要
目的探究布地奈德联合特布他林雾化吸入治疗婴幼儿毛细支气管炎的疗效及对肺功能、炎症因子水平的影响。方法将2014年1月至2017年1月入院的912例婴幼儿毛细支气管炎患儿,采用随机数表法分为研究组和对照组,每组456例。2组患儿均应用平喘祛痰、抗感染等常规治疗,研究组在此基础上加用布地奈德联合特布他林雾化吸入。观察2组治疗1w后疗效(症状体征缓解时间),评估2组治疗前后炎症因子[干扰素(IFN-γ)、白介素-4(IL-4)、白介素-6(IL-6)、肿瘤坏死因子(TNF-α)]变化情况,及治疗前后潮气呼吸肺功能指标[吸气/呼气时间比(Ti/Te)、达峰容积比(VPEF/VE)、达峰时间比(TPTEF/TE)、每千克潮气量(Vt/kg)]。结果 (1)治疗1w后,研究组症状缓解时间较对照组短(P<0.05);(2)治疗1w后,2组炎症指标水平均较治疗前下降(P<0.05),且研究组降幅较对照组大(P<0.05);(3)治疗1w后,2组肺功能指标水平均较治疗前升高(P<0.05),研究组增长较对照组大(P<0.05)。结论布地奈德联合特布他林雾化吸入治疗婴幼儿毛细支气管炎疗效良好,在增强药物抗炎作用的基础上促进患儿肺功能改善。
Objective To investigate the curative effect of budesonide combined with terbutaline aerosol inhalation on treatment of infants with bronchiolitis and its influence on lung function,inflammatory factor level.Methods 912 infants with bronchiolitis in our hospital from January 2014 to January 2017 were selected and randomly divided into observation group and control group,456 cases in each group.The two groups were all given expectorant and antiasthmatic activities,anti-infection.The observation group was given budesonide combined with terbutaline aerosol inhalation.Curative effect（symptom sign remission time） after 1w of the two groups was observed,inflammatory factor（IFN-γ,IL-4,IL-6,TNF-α） changing condition and tidal breath lung function indices（Ti/Te,EF/VE,TEF/TE,Vt/kg） of the two groups before and after treatment were evaluated.Results ① After 1w,symptoms remission time of the observation group was shorter than that in the control group（P〈0.05）;②After 1w,inflammation indexes level of the two groups were all declined compared with those before treatment（P〈0.05）,and the decreasing amplitude of the observation group was larger than that in the control group（P〈0.05）;③After 1w,lung function index level of the two groups were all increasd（P〈0.05）,and the increasing amplitude of the observation group was larger than that in the control group（P〈0.05）.Conclusion Budesonide combined with terbutaline aerosol inhalation on treatment of infants with bronchiolitis has better curative effect,it can not only enhance anti-inflammatory action but also promote lung function improvement.
作者
江瑞娟
Jiang Ruijuan(Department of Pediatrics,The Second People′s Hospital of Anyang City,Anyang 455000,China)
出处
《哈尔滨医药》
2018年第5期433-435,共3页
Harbin Medical Journal
