摘要
目的:探讨化浊解毒清肠方通过不同途径给药对早期肝硬化大鼠相关指标影响的研究。方法:将造模成功的40只早期肝硬化大鼠随机分为空白组、模型组、灌肠组、灌胃组。模型组予蒸馏水灌肠,每日2次,不施加其它干预措施,灌肠组和灌胃组分别每天给予2. 5 g/m L的水煎液,每日分2次;连续给药4周。结果:灌肠组大鼠肝脏组织病理学,血浆天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)水平较灌胃组明显减轻。结论:化浊解毒清肠方能够改善早期肝硬化大鼠的肝组织炎症,修复肝组织形态学损伤,在肝硬化治疗中灌肠途径给药具有明显优势。
Objective to study the effect of Huazhuo Jiedu Qingchang Recipe on related indexes of early cirrhosis rats. Methods： 40 early cirrhotic rats were randomly divided into blank group, model group, enema group and gastric lavage group. The model group was given enema with distilled water twice a day without any other intervention while the enema group and the gastric lavage group were given 2.5 g/ml water solution twice a day, for 4 weeks. Results： The liver histopathology, plasma aspartate aminotransferase （AST） and alanine aminotransferase （ALT） levels in the enema group were significantly lower than those in the gastric lavage group. Conclusion： Huazhuo Jiedu Qingchang Recipe can improve the inflammation of liver tissue and repair the morphological damage of liver tissue in early cirrhosis rats. It has obvious advantages in the enema route in the treatment of liver cirrhosis.
作者
苏春芝
李玉芳
杨泽江
赵宇玲
周顺
王瑞超
刘思雨
SU Chun-zhi;LI Yu-fang;YANG Ze-jiang;ZHAO Yu-ling;ZHOU Shun;WANG Rui-chao;LIU Si-yu(Shijiazhuang 050011)
出处
《河北中医药学报》
2018年第5期1-3,38,共4页
Journal of Hebei Traditional Chinese Medicine and Pharmacology
基金
河北省科技厅资助项目:No.20184117
关键词
化浊解毒清肠方
早期肝硬化
胁痛
积聚
癥积
给药途径
Huazhuo Jiedu Qingchang Recipe
early cirrhosis
hypochondriac pain
accumulation
accumulation of abdominal mass
administration route
