摘要
目的探讨重组人生长激素联合心理干预治疗特发性矮小症的临床效果,为特发性矮小症的治疗提供参考。方法将恩泽医院收治的80例特发性矮小症患儿随机分为对照组和观察组,每组40例;对照组给予常规营养支持,观察组在此基础上给予重组人生长激素联合心理干预治疗;比较2组患儿治疗前后的心理状况、胰岛素生长因子1(IGF-1)、胰岛素生长因子结合蛋白3(IGFBP-3)、生长参数及并发症等。结果治疗后,观察组患儿的情绪稳定性和汉密顿焦虑量表(HAMA)得分(3.49±1.25,7.52±2.48)均低于对照组(5.63±1.53,10.84±2.73)(t值分别为6.85,5.69,P值均<0.01);观察组患儿的IGF-1[(329.53±104.44)ng/mL],IGFBP-3[(4.07±1.18)μg/L]水平均明显高于对照组[(207.36±75.38)ng/mL,(3.31±0.94)μg/L](t值分别为6.00,3.19,P值均<0.01);观察组患儿的年生长速度、预测成年身高[(9.45±2.38)(169.27±8.36)cm]均明显高于对照组[(5.96±1.62)(164.41±9.54)cm](t值分别为7.67,2.42,P值均<0.05);2组治疗过程中的并发症发生率差异无统计学意义(12.5%,17.5%,P>0.05)。结论特发性矮小症患儿实施重组人生长激素联合心理干预治疗可缓解焦虑、稳定情绪、提高IGF-1和IGFBP-3水平,促进生长发育。
Objective To explore the clinical effect of treatment of recombinant human growth hormone combined with psychological intervention among idiopathic short stature patients, and to provide reference for the treatment of idiopathic short stature.Methods 80 cases of idiopathic short stature patients in Enze hospital were randomly divided into control group and observation group, 40 cases in each group, respectively. The control group was given conventional nutritional support, and the observation group was offered treatment of recombinant human growth hormone combined with psychological intervention. The indexes of mental status, serum Insulin like Growth Factor 1（ IGF-1） and Insulin-like Growth Factor Binding Protein 3（ IGFBP-3）, growth parameters and complications were compared between the two groups before and after treatment. Results After treatment, the scores of emotional stability（ 3.49±1.25） and Hamilton Depression Scale（ HAMA）（ 7.52±2.48） in the observation group were both lower than those of the control group（（ 5.63±1.53）,（ 10.84±2.73）,P〈0.01）. But the levels of IGF-1（ 329.53± 104.44） ng/m L, IGFBP-3（ 4.07±1.18） μg/L were both higher than those of the control group（（ 207.36±75.38） ng/ml,（ 3.31± 0.94） μg/L,P〈0.01）, growth rate（ 9.45±2.38） cm/year and adult height of prediction（ 169.27±8.36） cm in the observation group were all higher than the control group（ 5.96±1.62） cm/year,（ 164.41±9.54） cm, P〈0.05）. There was no statistical significance about incidence rate of complications between the two groups（ 12. 5%, 17. 5%, P 0. 05）. Conclusion The treatment of recombinant human growth hormone combined with psychological intervention among idiopathic short stature patients could relive anxiety, stablize emotion, raise levels of IGF-1 and IGFBP-3, and promote the growth and development of the body.
作者
陈秀芳
冯海英
蔡玲芳
管敏昌
CHEN Xiufang;FENG Haiying;CAI Lingfang;GUAN Minchang(Pediatrics Department of Enze Hospital in Taizhou Enze Medical Center（Group）,Taizhou（318050）,Zhejiang Province,China)
出处
《中国学校卫生》
CAS
北大核心
2018年第8期1210-1212,共3页
Chinese Journal of School Health
基金
浙江省中医药科技计划项目(2018ZA131)
关键词
生长激素
心理学
医学
研究
Growth hormone
Psychology
medical
Comparative study
作者简介
陈秀芳（1976-），女，浙江台州人，大学本科，副主任医师，主要研究方向为矮小症。
