摘要
目的观察分析苯巴比妥联合地西泮治疗热性惊厥患儿的临床效果及对血清S-100β与T淋巴细胞亚群的影响。方法选取2015年4月—2017年7月接受治疗的122例热性惊厥患儿进行观察研究。根据治疗方法不同分为观察组和对照组,每组61例。对照组给予地西泮治疗,观察组在对照组基础上联合苯巴比妥治疗。观察比较治疗后两组的临床疗效、血清神经元特异性烯醇化酶(NSE)、S-100β及T淋巴细胞亚群的变化情况,同时记录并发症发生情况。结果观察组的临床总有效率高于对照组(P<0.01)。治疗后,两组的血清NSE、S-100β以及CD8+水平低于治疗前,观察组低于对照组(P<0.05)。治疗后,两组CD4+和CD4+/CD8+水平高于治疗前,观察组高于对照组(P<0.05)。两组并发症总发生率比较差异无统计学意义(P>0.05)。结论苯巴比妥联合地西泮治疗小儿热性惊厥发挥了良好的协同作用,临床疗效肯定,同时可有效促进患儿免疫功能的恢复。
Objective To observe clinical efficacy of Phenobarbital combined with Diazepam in treatment of children with febrile convulsions and their effects on serum S-100β and T-lymphocyte subsets. Methods A total of 122 children with febrile convulsions during April 2015 and July 2017 were divided into observation group and control group （ n =61 for each group） according to different treatment methods. Control group was treated with Diazepam, while observation group was treated with Phenobarbital on the basis of treatment for control group. In two groups, clinical efficacy, changes of serum neuron specific enolase （NSE）, S-100β and T-lymphocyte subsets after treatment were observed and compared, and incidence rates of complications were also recorded. Results The total effective rate in observation group was higher than that in control group （ P 〈0.01）. After treatment, serum NSE, S-100β and CD8＋ levels were lower than those before treatment in two groups, and the levels in observation group were significantly lower than those in control group （ P 〈0.05）; values of CD4＋ and CD4＋/CD8＋ were significantly higher than those before treatment in two groups, and the values in observation group were significantly higher than those in control group （ P 〈0.05）. There was no significant difference in the total incidence rate of complications between two groups （ P 〉0.05）. Conclusion Phenobarbital combined with Diazepam in treatment of children with febrile convulsions may play good synergetic effect and clinical efficacy, and it may effectively promote recovery of immune function simultaneously.
作者
李刚
申迎春
张勇
LI Gang;SHEN Ying-chun;ZHANG Yong(Pediatric Intensive Care Unit,Northwest Women＇s and Children＇s Hospital,Xi＇an 710000,China)
出处
《解放军医药杂志》
CAS
2018年第9期101-104,共4页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
基金
陕西省自然科学基金资助(2015JM8436)
