摘要
目的探讨血清与胎盘组织中过氧化物酶体增殖物激活受体(PPAR)、脂肪酸结合蛋白-4(FABP-4)、整合素β1(ITGB1)对妊娠女性子痫前期发病的影响。方法选取自2015年3月至2017年7月在哈尔滨医科大学附属第四医院行剖宫产的妊娠女性167例为研究对象,按是否出现子痫前期症状分为正常组(n=118)和子痫前期组(n=49)。分别测定两组血清和胎盘组织中PPAR(PPARα、PPARβ、PPARγ)、FABP-4、ITGB1mRNA的含量,记录并比较两组围生儿病死率、新生儿窒息率、新生儿呼吸窘迫综合征发生率。结果两组血清和胎盘组织中的PPARα、PPARβ水平比较,差异无统计学意义(P>0.05);子痫前期组血清和胎盘组织中PPARγ水平均显著低于正常组,两组比较,差异有统计学意义(P<0.05);子痫前期组血清和胎盘组织中FABP-4、ITGB1mRNA水平均显著高于正常组,两组比较,差异有统计学意义(P<0.05)。子痫前期组围生儿病死率、新生儿窒息率、新生儿呼吸窘迫综合征发生率均高于正常组,两组比较,差异有统计学意义(P<0.05)。结论血清与胎盘组织中PPARγ水平降低、FABP-4及ITGB1水平升高可能促进子痫前期发病,对妊娠女性和新生儿的生命健康具有重要意义。
Objective To investigate the effects of peroxisome proliferators activate receptor（ PPAR）,fatty acid binding protein-4（ FABP-4） and integrin β1（ ITGB1） in serum and placenta on the incidence of preeclampsia in pregnant women. Methods A retrospective study was performed on 167 cases of patients who underwent cesarean section from March 2015 to July 2017. According to whether the patients had the symptoms of preeclampsia,167 pregnant women were divided into the normal group（ n = 118） and preeclampsia group（ n = 49）. The levels of PPARα,PPARβ,PPARγ,FABP-4 and ITGB1 mRNA in serum and placenta of the two groups were measured,respectively. Perinatal mortality,neonatal asphyxia and neonatal respiratory distress syndrome were calculated in both groups. Results There were no significant differences in the levels of PPARα and PPARβ between the two groups（ P〈0. 05）. The levels of PPARγ in the serum and placenta of the preeclampsia group were significantly lower than those in the normal group（ P〈0. 05）. The levels of FABP-4 and ITGB1 mRNA in serum and placenta of preeclampsia group were significantly higher than those in control group（ P〈0. 05）. The rates of perinatal mortality,neonatal asphyxia and neonatal respiratory distress syndrome in the preeclampsia group were higher than those in the normal group（ P〈0. 05）. Conclusion In serum and placental tissues,reduced level of PPAR γ and FABP-4,increased levels of ITGB1 may promote the onset of preeclampsia,which has great significance to the life and health of pregnant women and newborns.
作者
王利微
杨海鹏
蔡雁
WANG Li-wei;YANG Hai-peng;CAI Yan(Depamnent of Obstetrics,The Fourth Affiliated Hospital of Harbin Medical University,Harbin 150000,China)
出处
《临床军医杂志》
CAS
2018年第7期763-766,共4页
Clinical Journal of Medical Officers
基金
国家自然科学基金(31471113)
作者简介
王利微（1982-），女，黑龙江庆安人，医师;通信作者：蔡雁，E-mail：caiyan318@126．com
