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脑白质病变患者临床特征及其发病影响因素分析 被引量:3

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摘要 目的分析脑白质病变(WML)患者的临床特征及其发病影响因素。方法回顾性分析214例WML患者的临床资料,以同期64例健康体检者作为对照。采集完整的临床资料,包括年龄、性别、吸烟史、饮酒史、高血压、糖尿病、冠心病、BMI;行头颅MRI检查;应用全自动生物化学分析仪检测血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(APO-A1)、载脂蛋白B(APO-B)、C-反应蛋白(CPR)、纤维蛋白原(FIB)、尿酸(UA)水平。比较WML患者和无WML者的临床病理特征,采用Logistic回归分析WML的影响因素。结果 WML患者年龄、高血压患者比例及血清TC、LDL-C、CRP、FIB、UA水平均高于无WML者(P均<0.05)。多因素Logistic回归分析结果显示,年龄(OR=2.674,95%CI为1.954~1.130,P<0.001)、高血压(OR=1.856,95%CI为1.265~2.457,P=0.005)、TC(OR=2.341,95%CI为1.702~4.568,P=0.002)、UA(OR=1.007,95%CI为1.017~1.043,P=0.003)是WML的影响因素。结论 WML患者年龄较大,高血压患病率较高,血清TC、LDL-C、CRP、FIB、UA水平升高;年龄增长、高血压、TC及UA水平升高均可增加WML发病风险。
出处 《山东医药》 CAS 2018年第26期52-54,共3页 Shandong Medical Journal
作者简介 通信作者:窦志杰(E-mail:douzj9812@sina.com)
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