摘要
目的:分析中药制剂临床发生的不良反应并探讨相关药物管理的改进方法。方法:回顾分析了自2014年2月至2016年3月在我院因临床使用中药制剂而引发不良反应的194例病例,根据患者的年龄、性别、药物种类、给药方式、发生时间等,对不良反应的发生情况进行分析比较。结果:所有患者中,>60岁的老年患者及<15岁的青少年患者所占比例最大,分别为40.2%和30.4%。发生不良反应最多的前5位的中药制剂为红花注射液、舒血宁注射液、华蟾素注射液、丹参注射液和灯盏花素注射液。静脉滴注(33.5%)和静脉推注(37.6%)是发生不良反应最多的给药方式。79.9%的患者在用药1 h内发生不良反应。不良反应主要累及的器官是皮肤,占所有病例的50%。不良反应发生后,患者经相应处理,治愈率为79.4%,好转率为20.6%。结论:中药制剂发生不良反应的原因较多,临床在使用中药制剂时,需加强规范操作,提高管理和监控力度,减少不良反应的发生。
Objective： To analysis clinical adverse drug reaction of Chinese traditional preparation and to explore the improvement of drug management. Methods： A retrospective study of 194 cases which had adverse drug reaction of Chinese traditional preparation from February 2014 to March 2016 in our hospital were performed. Those cases were analyzed based on ages, genders, kinds of drug, modes of administration, occurrence time point and so on. Results： In all patients, the ratio of those aged more than 60 or less than 15 were most,40.2% and 30.4% respectively. The top 5 Chinese traditional preparation with adverse drug reaction were Honghua injection（红花注射液）, Shuxuening injection（舒血宁注射液）, Huachansu injection（华蟾素注射液）,Danshen injection（ 丹参注射液） and Dengzhanhuasu injection（ 灯盏花素注射液）. Intravenous drop infusion（33.5%） and intravenous push（37.6%） were the most frequent modes of administration. 79.9% patients had adverse drug reaction within 1 hour after given drugs. Skin was the most involved organism in adverse drug reaction of Chinese traditional preparation and the rate was up to 50%. After corresponding treatments for adverse drug reaction, the curative ratio was 79.4% and the improvement ratio was 20.6%. Conclusion： There were many reasons for adverse drug reaction of Chinese traditional preparation. In the clinical use of traditional Chinese medicine preparation, it is necessary for us to strengthen standardized operation, improve management and monitoring efforts, to reduce the incidence of adverse reactions.
作者
莫望春
汪锦飘
MO Wang-chun;WANG Jing-piao(Peking University Shenzhen Hospital, Shenzhen Guandong 518036, China;Sun Yat-sen Memorial Hospital, Guangzhou Guangdong 510120, China)
出处
《中医药导报》
2018年第13期62-65,共4页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
关键词
中药制剂
不良反应
药物管理
Chinese traditional preparation
adverse drug reaelion
drug management
