摘要
目的:分析东莞市中药饮片所致药物不良反应(adverse drug reactions,ADRs)的流行病学特点,为中药饮片的安全、合理使用提供参考。方法:选取2017年1月—2020年12月东莞市药品不良反应监测中心收集到的211例中药饮片的ADRs报告,采集ADRs患者的年龄、性别、所涉药物、累及器官及其临床表现、最终转归等信息,分析中药饮片所致ADRs的发生规律与特点。结果:211例ADRs患者中,女性明显多于男性(142例vs 69例),年龄上>20~30岁分布稍多(47例,占22.27%),而其他年龄段分布较为均匀;经过处置后,治愈的有174例(占82.46%),剩余的也均好转(37例,占17.54%);211例ADRs主要累及消化系统(134例,占63.51%),临床表现为肠鸣、大便异常、恶心、呕吐等,其次为皮肤或黏膜(44例,占20.85%);211例ADRs涉及的药物主要为补虚类(62例,占29.38%),其次为解表类(27例,占12.80%)、活血化淤类(22例,占10.43%)和清热类(20例,占9.48%)。结论:中药饮片虽然是临床上较为安全的药物,但仍有发生ADRs的风险,临床医生在开具中药饮片时有必要叮嘱用药注意事项和基本的处理原则,以确保患者的用药安全。
Objective:To analyze the epidemiological characteristics of adverse drug reactions(ADRs)caused by Chinese herbal pieces in Dongguan,and provide reference for the safe and rational use of Chinese herbal pieces.Methods:The ADR reports of Chinese herbal pieces in 211 cases collected from Dongguan Center for Adverse Drug Reaction Monitoring from January 2017 to December 2020 were selected,the information of patients with ADRs,such as age,gender,drugs involved,organs involved and their clinical manifestations,final outcomes,etc.,was collected,and the rules and characteristics of the occurrence of ADRs caused by Chinese herbal pieces were analyzed.Results:Among the 211 patients with ADRs,the number of female patients was significantly more than that of male patients(142 cases vs 69 cases),those at the age of over 20-30 years old were slightly more(47 cases,22.27%),and the distribution of other age groups was relatively uniform.After treatment,174 cases(82.46%)were cured,and the rest(37 cases,17.54%)were also alleviated;211 cases of ADRs mainly involved the gastrointestinal system(134 cases,63.51%),with the clinical manifestations of borborygmus,abnormal stool,nausea,vomiting,etc.,followed by skin or mucous membranes(44 cases,20.85%).The drugs mainly involved in the 211 cases of ADRs were mainly drugs for tonifying deficiency(62 cases,29.38%),drugs for relieving exterior syndromes(27 cases,12.80%),drugs for activating blood circulation to dissipate stasis(22 cases,10.43%)and drugs for clearing heat(20 cases,9.48%).Conclusion:Although Chinese herbal pieces are relatively safe drugs in clinical practice,there is still a risk of ADRs.Clinicians should repeatedly advise the matters needing attention for medications and basic principles of handling when prescribing Chinese herbal pieces to ensure the safety of medication for patients.
作者
魏美贤
刘莹
罗伟
黎秀平
汤远亮
王衍洪
WEI Mei-xian;LIU Ying;LUO Wei;LI Xiu-ping;TANG Yuan-liang;WANG Yan-hong(Department of Pharmacy,Dongguan Songshan Lake Tungwah Hospital,Dongguan Guangdong 523808,China;Dongguan Institute for Food and Drug Control,Dongguan Guangdong 523808,China)
出处
《抗感染药学》
2023年第5期486-489,共4页
Anti-infection Pharmacy
基金
广东省药品监督管理局2022年市县药品监管综合改革创新项目(编号:ZG-DS-2022021)
东莞市社会发展科技项目(编号:20211800901922)。
关键词
中药饮片
药物不良反应
流行病学特点
合理用药
Chinese herbal piece
adverse drug reaction
epidemiological characteristic
rational medication
作者简介
魏美贤(1996-),女,中药师;通信作者:罗伟(1986-),女,主管药师,电子邮箱:842309320@qq.com。
