摘要
目的探讨妊娠合并乙肝病毒(hepatitis B virus,HBV)感染及乙型肝炎E抗原(hepatitis B e antigen,HBeAg)阳性状态对母婴结局的影响。方法选取2008年6月~2017年9月于武汉市妇女儿童医疗保健中心分娩的1 463例乙肝孕妇作为病例组,另按照1∶1个体匹配的方式选取前后一月时间内在该机构分娩的1 463例健康孕妇作为对照组。在此基础上,按照乙肝血清学标志物结果,将所有纳入的研究对象分成正常对照组、乙肝表面抗原(hepatitis B surface antigen,HBsAg)(+)和HBeAg(-)组(单阳性组)、HBsAg(+)和HBeAg(+)组(双阳性组)。收集孕产妇一般信息、妊娠并发症情况以及新生儿信息,分别比较上述三组的一般情况、各项妊娠不良结局的发生情况。结果单阳性组妊娠高血压的发生风险是正常对照的2.74倍(95%CI:1.09~6.90,P=0.033);双阳性组妊娠期高血压的发生风险是正常对照的6.67倍(95%CI:1.29~34.48,P=0.023)。单阳性组剖宫产的发生风险是正常对照的1.15倍(95%CI:1.03~1.29,P=0.010);双阳性组则为正常对照的1.53倍(95%CI:1.24~1.88,P<0.001)。结论乙肝感染会增加孕妇妊娠期高血压和以剖宫产作为其分娩方式的风险。
Objective To investigate the impact of chronic hepatitis B and hepatitis B e antigen （HBeAg） status on maternal and infant perinatal outcomes. Methods A total of 1 463 pregnant women with hepatitis B virus（HBV） who gave birth at Wuhan Women and Children Medical and Healthcare Center from June 2008 to September 2017. Additionally, 1 463 healthy pregnant women who delivered at the same hospital within a month （ earlier or later） were selected as the con- trol group, according to the intention of 1 control for every case. All subjects were divided into three groups： normal control group, hepatitis B surface antigen （ HBsAg ） （ ＋ ） and HBeAg （ - ） group （ single-positive group ） , HBsAg （ ＋ ） and HBeAg（ ＋ ） group（ double-positive group）. The pertinent information including general characteristics of pregnant women, pregnancy complications, and neonatal information were collected. The general characteristics and the occurrence of ad- verse maternal and infant outcomes of the above three groups were compared. Results Single-positive group （ OR = 2. 74, 95% CI： 1.09-6. 90, P =0. 033） and double-positive group （ OR = 6. 67, 95% CI： 1.29-34. 48, P = 0. 023 ） both had higher risk of gestational hypertension. Also, single-positive group（ OR = 1.15, 95% CI： 1.03-1.29, P = 0. 010） and double-positive group（ OR = 1.53,95% CI： 1.24-1.88, P 〈 0. 001 ） both had significantly higher rate of cesarean section. Conclusions Hepatitis B virus infection was associated with the higher risk of gestational hypertension and cesarean section.
作者
陈红燕
李秀
彭松绪
杜玉开
CHEN Hong-yan;LI Xiu;PENG Song-xu;DU Yu-kai(Department of Maternal and Child Health, School of Public Health, Ton~i Medical College, Hua- zhong University of Science and Technology, Wuhan 430030, Chin)
出处
《中华疾病控制杂志》
CAS
CSCD
北大核心
2018年第6期617-620,共4页
Chinese Journal of Disease Control & Prevention
基金
国家自然科学基金(81573166)
关键词
乙型肝炎
肝炎e抗原
乙型
母婴结局
Hepatitis B
Hepatitis B e antigens
Maternal and infant outcomes
作者简介
陈红燕（1991-），女，重庆人，在读硕士研究生。主要研究方向：妇幼保健。;【通讯作者】杜玉开，E-mail：duyukai2000@163．com.
