摘要
目的 探讨宁波市鄞州区孕妇HBV感染现状及HBV宫内感染的相关危险因素,为临床HBV预防提供参考依据.方法 对首次在某医院建立保健卡的1100名孕妇予以调查问卷分析,同时采用化学发光法检测孕妇的血清乙肝标志物,依据结果对182名外周血乙型肝炎表面抗原(hepatitis B surface antigen,HBsAg)阳性孕妇进行随访直至孕妇分娩.采集孕妇分娩时的胎盘组织及脐血,采用酶联免疫吸附法(enzyme linked immunosorbent assay,ELISA)检测脐血HBsAg,采用荧光定量PCR检测孕妇的气血HBV-DNA,采用免疫组织化学法检测胎盘组织的HBsAg,采用非条件logistic回归分析及χ2检验分析HBV宫内感染影响因素.结果 1100名孕妇中,发现182名孕妇呈HBsAg阳性,HBV感染率为16.55%.通过脐血检测,发现182名孕妇中发生HBV宫内感染者共36名,HBV感染率为19.78%.调查结果显示孕妇HBV宫内感染的主要危险因素包括:孕前超重、胎盘HBsAg呈阳性、孕妇血清乙型肝炎E抗原(HBeAg)呈阳性(OR=3.377、5.155、4.651,P<0.05).结论 对于HBsAg、HbeAg均呈阳性且肥胖孕妇,发生HBV宫内感染的几率较大,必须给予高度重视,需要提高孕妇自身防护意识,加强预防措施,从而合理规避感染风险.
Objective To explore the status quo of HBV infection in pregnant women in Yinzhou District of Ningbo City and related risk factors of HBV intrauterine infection,and provide reference for clinical HBV prevention.Methods Questionnaire analysis was conducted on 1 100 pregnant women who first established health cards in the hospital,simultaneously chemiluminescence was used to detect serum hepatitis B markers in pregnant women.According to the results,182 pregnant women with hepatitis B surface antigen(HBsAg)positive were followed up until the pregnant woman gave birth,and the placental tissue and cord blood of pregnant women during childbirth were collected.The umbilical cord blood HBsAg was detected with enzyme linked immunosorbent assay(ELISA),the blood and blood HBV-DNA of pregnant women was detected with real-time PCR,and the HBsAg of the placenta tissue was detected with immunohistochemistry.Unconditional logistic regression analysis andχ2 test were used to analyze the influence factors of HBV intrauterine infection.Results Among the 1 100 pregnant women,182 pregnant women were found to be HBsAg positive,and the HBV infection rate was 16.55%.Through cord blood test,a total of 36 HBV intrauterine infections occurred in 182 pregnant women,and the HBV infection rate was 19.78%.The survey results showed that The main risk factors for HBV intrauterine infection in pregnant women included pre-pregnancy overweight,placental HBsAg positive,and maternal serum hepatitis B E antigen(HBeAg)positive(OR=3.377,5.155,4.651,P<0.05).Conclusion For obese pregnant women with HBsAg and HbeAg positive,the incidence of HBV intrauterine infection is large,so they must be given high priority,and they need to improve their own protection awareness,strengthen preventive measures,so as to avoid the risk of infection.
作者
曾小医
何小玲
徐丽丽
黄梦佳
Zeng Xiaoyi;He Xiaoling;Xu Lili;Huang Mengjia(Delivery Room,Ningbo Yinzhou People's Hospital,Ningbo 315400,China)
出处
《中国医院统计》
2019年第4期319-320,H0001,共3页
Chinese Journal of Hospital Statistics
基金
浙江省医药卫生科技计划项目(2018KY751)
关键词
孕妇
HBV感染
HBV宫内感染
危险因素
调查
pregnant woman
HBV infection
HBV intrauterine infection
risk factor
investigation
作者简介
通信作者:曾小医,Email:z121513539@163.com
