摘要
中枢神经损伤的修复是当今社会的一大难题。随着纳米技术的发展,逐渐出现一些能产生导电性的生物材料如碳纳米管和石墨烯等,它们在一定程度上能促进神经的功能性恢复,但其本身对机体也有一定的毒性,甚至有时引起神经细胞凋亡。神经损伤过程往往出现神经轴突的断裂,断裂的神经轴突无法与次级神经元发生突触连接,导致神经的修复再生障碍。神经轴突导向因子netrin-1是神经发育过程中的重要分泌蛋白,可定向牵引神经轴突的生长和迁移,导致突触形成,从而促进神经损伤的修复。但是它在纳米材料修复神经损伤中的分子调节机制尚不明确。本文综述了netrin-1在纳米材料促进神经再生中的作用。它对神经元的轴突导向生长和神经迁移具有促进作用,抑制纳米材料造成的神经损伤和凋亡,为其应用于纳米材料修复神经损伤且诱导神经再生提供重要理论依据。
Nerve regeneration is a major problem in our society after nerve injury. With the development of nanotechnology, some nano-materials, such as carbon nanotubes and graphene with electrical conductivity, have been used to promote neuronfunctional recovery. Some of the nano-materials,however, are neurotoxic and cause neuronal apoptosis. Nerve injury often leads to the disruption of axons,and broken axons cannot form synapse with target neurons, which affects the repair and regeneration of nerves. Netrin-1 is an important cue in neurogenesis, which can guide the growth and migration of axons and synapse formation during neuronal regeneration. However, some growth factors are used to decorate the surface of nanomateriaes to decrease the toxicity in medicine, but the molecular mechanism by which netrin-1 mediates the toxicity of nanomaterials is not clear yet. In this study, we investigated the nano-materials and the function of netrin-1 in neuronal regeneration in recent years. We have proved that netrin-1 can not only guide the growth and migration of axon and synapse formation, but also promote functional recovery of the neurons which are injured by the toxicity of nanomaterials. Our review will provide a theoretical basis for neuronal regeneration by nanomaterials.
作者
贾正泰
张志发
赵钰琛
刘美丽
JIA Zheng-tai;ZHANG Zhi-fa;ZHAO Yu-chen;LIU Mei-li(Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China;Beijing Advanced Innovation Centre for Biomedical Engineering, Beihang University, Beijing 102402, China)
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
2017年第12期1201-1207,共7页
Chinese Journal of Pharmacology and Toxicology
基金
国家自然科学基金(31470901)~~
作者简介
刘美丽，北京航空航天大学生物与医学工程学院，副教授。北京航空航天大学“蓝天科研新星”。中国生理学会和中国生物医学工程学会会员。主要从事神经再生修复研究。承担国家自然科学基金项目2项，参与国家重大研发项目1项。在Nanoscale，Neurotox Res，PlosOne和Neurosci Lett等SCI期刊发表论文20余篇，EI论文1篇，其中第一作者SCI论文10篇。多次参加国际生物力学会议和神经科学会议，并做大会报告。通讯作者：刘美丽，E-mail：liuml@buaa．edu．cn，Tel：（010）82314878
