摘要
目的:观察依降钙素联合归甲止痛胶囊治疗退变性腰椎管狭窄症的有效性和安全性。方法:将2016年4月至2017年9月本科就诊的退变性腰椎管狭窄症患者按就诊顺序随机分为两组:观察组(38例)予依降钙素肌注并配合本院制剂归甲止痛胶囊口服;对照组(38例)单纯予以依降钙素肌注。对所有患者均进行40d的随访。采用视觉模拟疼痛评分(Visual Analogue Scale,VAS)、行走时被迫下蹲或休息时间、夜间睡眠时间、日本骨科学会评分(Japanese Orthopaedic Association,JOA)对纳入患者进行评估。定期对患者进行随访,记录相关测量数据。结果:两组患者治疗20d后腰腿痛、行走时被迫下蹲或休息时间均改善,但对照组治疗20d和40d后VAS评分、行走时被迫下蹲或休息时间均大于观察组,差异有统计学意义(P<0.05);两组患者治疗10d后夜间睡眠时间均延长,但对照组治疗10,20及40d后夜间睡眠时间均短于观察组,差异有统计学意义(P<0.05);两组患者治疗10d后JOA评分改善指数、改善率均提高,但对照组治疗10,20及40d后JOA评分改善指数、改善率均低于观察组,差异有统计学意义(P<0.05)。结论:退变性腰椎管狭窄症给予依降钙素联合归甲止痛胶囊可减轻因退变性腰椎管狭窄导致的腰腿痛及功能障碍,并能有效延长夜间睡眠时间。
Objective：To observe the efficacy and safety of calcitonin combined with Guijia Zhitong capsule in the treatment of degenerative lumbar spinal stenosis.Methods：The patients with degenerative lumbar spinal stenosis treated from April 2016 to September 2017 were randomly divided into two groups.The observation group（n=38）was given calcitonin intramuscular injection combined with Guijia Zhitong capsule,and the control group（n=38）was simply administered with calcitonin intramuscular injection only,all patients were followed up for 40 days.The visual analogue scale（VAS）,walking was forced to squat or rest time,sleep time during the night and the Japanese Orthopedic Association（JOA）were used to evaluate the effect.Patients were followed up on a regular basis,and the relevant measurement data was recorded.Results：Two groups of patients with waist and leg pain after 20 days of treatment,walking was forced to squat or rest time were improved.But the VAS score,walking was forced to squat or rest time in the control group were greater improved than the observation group at 20,40 days after treatment（P〈0.05）.The sleep time during the night was prolonged in both groups 10 days after treatment,but sleep time during the night in the control group was shorter than that in the observation group 10,20 and 40 days after treatment（P〈0.05）.The JOA score were improved in both groups 10 days after treatment,but the JOA score in the control group were improved lower than those in the observation group（P〈0.05）.Conclusion：The calcitonin combined with Guijia Zhitong capsules is effective for degenerative lumbar spinal stenosis,which can reduce waist and leg pain,improve oswestry disability,and can effectively extend the sleep time during the night.
作者
梁雄勇
张宝鉴
孙润芳
薛为民
赵聚峰
潘星源
刘建雄
刘俊
LIANG Xiongyong;ZHANG Baojian;SUN Runfang;XUE Weimin;ZHAO Ju feng;PAN Xingyuan;LIU Jianxiong;LIU Jun(Shanxi Provincial Hospital of Traditional Chinese Medicine,Taiyuan 030012,China;Shanxi University of Traditional Chinese Medicine, Taiyuan 030024,China.)
出处
《中国中医骨伤科杂志》
CAS
2018年第5期10-13,18,共5页
Chinese Journal of Traditional Medical Traumatology & Orthopedics
基金
山西省中医药研究院院级课题(2016ZJ01)
关键词
依降钙素
归甲止痛胶囊
退变性腰椎管狭窄症
calcitonin
Guijia Zhitong capsule
degenerative lumbar spinal stenosis
作者简介
通信作者:薛为民,E-mail:lc325007@163.com
