摘要
目的探讨淋巴瘤合并实体肿瘤的多原发癌临床特征，以提高临床工作者对多原发癌的认识。方法回顾性分析2012年3月至2017年10月收治的17例明确诊断为淋巴瘤合并原发实体肿瘤的患者资料，并结合文献对其临床特征、治疗及转归进行总结。结果①17例患者中，男8例，女9例，中位年龄57（30～78）岁。②淋巴瘤：分类：霍奇金淋巴瘤1例，B细胞淋巴瘤2例，边缘区淋巴瘤6例，弥漫大B细胞淋巴瘤3例，套细胞淋巴瘤1例，结外NK／T细胞淋巴瘤（鼻型）3例，问变大细胞淋巴瘤l例；AnnArbor分期：Ⅰ期6例，Ⅱ期1例，Ⅲ期2例，Ⅳ期4例，不确定4例。③实体肿瘤：分类：消化道恶性肿瘤8例（食管癌3例，胃癌3例，结直肠癌2例），甲状腺癌7例（乳头状癌3例，微小乳头状癌4例），肝癌1例，肺癌1例；分期：Ⅰ期10例，Ⅲ期3例，Ⅳ期2例，不确定2例。④17例患者中有15例接受手术治疗，部分患者联合化疗、放疗、auto—HSCT治疗。3例患者治疗未结束，2例失访，4例死亡，3例完全缓解，3例病情稳定，2例复发或进展。结论淋巴瘤与实体肿瘤之间的关系目前虽暂无定论，但二者在发生、发展过程中存在一定的相关性，淋巴瘤合并实体肿瘤虽然少见但并不罕见，临床工作者应该提高认识，避免误诊和漏诊。
Objective To explore the clinical features of patients with synchronous lymphoma and carcinoma. Methods The clinical data of 17 patients with Synchronous lymphoma and carcinoma from February 2012 to October 2017 were analyzed retrospectively. Results Among 17 patients of lymphoma, 1 case HL, 2 cases B-NHL, 6 cases MZBL, 3 cases DLBCL, 1 case mantle cell lymphoma（MCL）, 3 cases NK/T- cell lymphoma, 1 case anaplastic large cell lymphoma（ALCL）. In terms of 17 patients with carcinoma, 3 cases esophageal carcinoma, 3 cases gastric carcinoma, 2 cases colorectal carcinoma, 7 cases thyroid carcinoma, 1 case hepatocellular carcinoma and lung cancer. Up to 15 patients received operation, and some of them combined with chemotherapy, radiotherapy and autologous transplant. Follow-up analysis showed that 3 cases was undergoing treatment, 2 cases lost follow-up, 4 cases died, 3 cases achieved CR, 3 cases remained to be at SD, and 2 cases assessed for progression or recurrence. Conclusion The relationship between lymphoma and carcinoma was under discussion, patients with synchronous lymphoma and carcinoma were not unusual. We herein should raise awareness to avoid misdiagnosis.
作者
熊媛媛
刘志娟
陈琳
袁芳芳
尹青松
米瑞华
张冰
杜建伟
张青兰
林全德
张丽娜
高雪
董丽华
李玉富
宋永平
魏旭东
Xiong Yuanyuan;Liu Zhijuan;Chen Lin;Yuan Fangfang;Yin Qingsong;Mi Ruihua;Zhang Bing;Du Jianwei;Zhang Qinglan;Lin Quande;Zhang Li＇ ha;Gao Xue;Dong Lihua;Li Yufu;Song Yongping;Wei Xudong.(Department of Hematology Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, Chin)
出处
《中华血液学杂志》
CAS
CSCD
北大核心
2018年第4期277-280,共4页
Chinese Journal of Hematology
关键词
淋巴瘤
肿瘤
多原发性
幽门螺杆菌
Lymphoma
Neoplasms, multiple primary
Helicobacter pylori
作者简介
通信作者：魏旭东，Email：xudongwei@zzu．edu．cn
