摘要
目的了解法舒地尔联合丹参治疗对下肢动脉硬化闭塞症(ASO)患者应激状态的影响。方法以2014年1月至2016年12月诊治的ASO患者160例为研究对象,患者随机分为试验组和对照组,每组80例。选取同期体检的正常者50例作为正常对照组。对照组给予丹参注射液20 ml加入5%葡萄糖注射液500 ml,静脉滴注,1次/d,给药2周;试验组在使用丹参注射液的基础上给予法舒地尔30 mg/次,加入0.9%氯化钠溶液100 ml,静脉滴注,8 h/次,给药2周。2组患者其他治疗措施无差异。记录ASO患者的症状改善情况及药物相关不良反应。检测ASO患者及正常对照组的氧化应激指标丙二醛(MDA)、超氧化物歧化酶(SOD)、硫氧还蛋白(TRX)、髓过氧化物酶(MPO)活性及炎性因子(IL-8、IL-6、CRP等)的水平;并检测试验组和治疗对照组ASO患者治疗前后氧化应激指标及炎性因子的变化情况。结果试验组和治疗对照组患者均顺利完成治疗,试验组在提高临床疗效、改善症状方面优于治疗对照组(P<0.05);试验组和治疗对照组的不良反应发生率差异无统计学意义(P>0.05)。ASO患者的部分氧化应激指标及炎性因子与正常对照组差异有统计学意义(P<0.05)。氧化应激指标及炎性因子在治疗后均比治疗前有明显改善,差异有统计学意义(P<0.05);试验组改善比治疗对照组改善更为明显(P<0.05)。结论 ASO患者存在明显的应激状态。法舒地尔联合丹参可有效减轻机体的应激,对ASO治疗有较好的效果。
Objective To investigate the effects of fasudil combined with Danshen on stress status of patients with arteriosclerosis obliterans（ ASO） of lower extremity. Methods A total of 160 patients with arteriosclerosis obliterans of lower extremity who were treated in our hospital from January 2014 to December 2016 were randomly divided into experimental group and control group,with 80 patients in each group,at the same time,the other 80 healthy subjects were served as normal control group. The patients in control group were given Danshen injection 20 ml in 5% glucose injection 500 ml by intravenous infusion,once a day for 2 weeks,however,the patients in experimental group,on the basis of control group,were given fasudil 30 mg in0. 9% sodium chloride solution 100 ml by intravenous infusion,once at an interval of 8 hours,for 2 weeks. The clinical effects,the drug related adverse effects,and the levels of MDA,SOD,TRX,MPO,IL-8,IL-6,and CRP were observed and compared among the three groups. Results The clinical curative effects and improvement of symptoms in experimental group were superior to those in control group（ P〈0. 05）. However there were no significant differences in incidence rates of adverse effects between experimental group and control group（ P〈0. 05）. Moreover there were significant difference in some oxidative stress indexes and inflammatory factors between experimental group and normal control group（ P〈0. 05）. After treatment,the oxidative stress indexes and inflammatory factors were improved in experimental group and control group,as compared with those before treatment（ P〈0. 05）,moreover,the improvement degree in experimental group was more significant than that in control group（ P〈0. 05）. Conclusion The obvious stress status exists in patients with ASO,and fasudil combined with Danshen can effectively relieve the stress status of patients,which has better therapeutic effects on ASO.
出处
《河北医药》
CAS
2018年第4期542-546,共5页
Hebei Medical Journal
关键词
法舒地尔
丹参
下肢动脉硬化闭塞症
应激
fasudil
Danshen
arteriosclerosis obliterans of lower extremity
stress
作者简介
通讯作者：吕柏楠，050051石家庄市，河北省人民医院普外二科；E-mail：shixiaoming1999@126．com
