摘要
目的分析莫西沙星相关皮肤变态反应的发生率、发生特征及影响因素,为临床用药提供参考。方法利用"医疗机构ADE主动监测与智能评估警示系统"中的"皮肤变态反应"模块,回顾性调取本院2015年1月-2016年12月期间使用莫西沙星的住院患者病历。经临床药师再评价系统报警病例,获得莫西沙星致皮肤变态反应的发生率与发生特征;并利用巢式病例对照研究设计对影响因素进行分析。结果借助系统自动监测7774例次莫西沙星用药患者,用时约1 h;皮肤变态反应发生率为0.53%(95%CI:0.36%~0.71%)。多因素Logistic回归分析显示,饮酒为莫西沙星致皮肤变态反应的影响因素,OR值为5.968(95%CI:1.213~29.371)。结论莫西沙星相关皮肤变态反应的发生率属于偶见范围,且未见严重ADR。本系统可以高效快捷开展药源性皮肤变态反应的自动监测。
Objective To analyze the incidence and risk factors of moxifloxacin-related adverse skin reactions with active surveillance and assessment system of adverse drug events. Methods The data of inpatients in our hospital from January in 2015 to December in 2016 were analyzed retrospectively with event configuration parameters of ＂allergic reaction＂ modular. After re-evaluation by clinical pharmacists, the incidence of moxifioxacin-related adverse skin reactions was analyzed. Nested case-control study was adopted to analyze the risk factors of moxifloxacin-related adverse skin reactions. Results A total of 7774 cases using moxifloxacin were automatically surveilled, and the running time of this system was about 1 hour. The incidence of adverse skin reactions was 0.53% （95%CI： 0.36% -- 0.71%）. The multivariate Logistic regression analysis showed alcohol was associated with moxifloxacin-related adverse skin reactions （OR： 5.968; 95% CI： 1.213 -- 29.371）. Conclusion The incidence of moxifloxacin-related adverse skin reactions is relatively low. Severe ADRs are not found. This system can surveil automatic moxifioxacin-related adverse skin reactions quickly and efficiently.
出处
《中南药学》
CAS
2017年第11期1505-1508,共4页
Central South Pharmacy
基金
2014年全军后勤科研重点项目(编号:BWS14R039)
关键词
莫西沙星
皮肤类不良反应
自动监测
巢式病例对照
moxifloxacin
adverse skin reaction
automatic surveillance
nested case-control study
作者简介
贾王平，男，药帅，硕士研究生，主要从事临床药学工作，Tel：18519196066，E-mail：18519196066@163．com;郭代红，史，主任药师，硕卜研究生导师，主要从事临床约学与药物警戒研究，Tel：（OlO）66937146，E-mail：guodh301@163．com.
