摘要
目的评价不同免疫疗法对强直性脊柱炎(AS)患者血清ESP、CRP及PLT水平的影响。方法纳入62例AS患者按照随机数字表法分为2组,对照组和研究组各31例;两组均给予柳氮磺吡啶肠溶片治疗,对照组同时给予口服沙利度胺,研究组给予重组人Ⅱ型肿瘤坏死因子受体抗体融合蛋白(rh TNFR:Fc)皮下注射。比较2组患者治疗前后红细胞沉降率(ESR)、血清C反应蛋白(CRP)及血小板计数(PLT)水平。结果治疗后,与对照组比较,研究组患者ESR血清CRP水平较低(P<0.05)。研究组患者BASDAI评分、关节疼痛程度、晨僵时间、腰椎活动度试验及扩胸度均优于对照组,研究组总有效率高于对照组,差异均有统计学意义(P<0.05)。结论 rh TNFR:Fc联合柳氮磺吡啶治疗AS,临床疗效显著,值得借鉴和推广。
Objective To explore the effect of different immunotherapy on serum ESP, CRP and PLT in patients with ankylosing spondylitis. Methods 62 cases of patients with ankylosing spondylitis were chosen and were divided into the control group and the research group according to the random number table method with 31 cases in each group; The two groups were given the treatment of sulfasalazine enteric-coated Tablets orally. At the same time, the control group was treated with Thalidomide, while the research group was treated with rhTNFR： Fc through subcutaneous injection. ESR, CRP and PLT level of two groups were compared before and after treatment. Results After treatment, compared with the control group, the ESR and the serum level of CRP were lower in the experimental group（P 〈 0.05 ; Also, the scores of BASDAI score,joint pain degree, morning stiffness time, lumbar vertebra activity test and extension degree were all better than those of the control group. The total effective rate of the study group was higher than that of the control group （ P 〈 0.05 ）. Conclusion The rhTNFR： Fc combined with sulfasalazine treatment of AS has remarkable clinical efficacy and it is worth applied and promoted.
作者
黄勤
毛慧慧
HUANG Qin;MAO Hui- hui(Nephritic Syndrome Enshi Tujia and Miao Autonomous Prefecture Central Hospital ,Enshi 445000, Chin)
出处
《标记免疫分析与临床》
CAS
2017年第12期1396-1398,1431,共4页
Labeled Immunoassays and Clinical Medicine
关键词
红细胞沉降率
C反应蛋白
血小板计数
强制性脊柱炎
Erythrocyte sedimentation rate
Serum C reactive protein
Platelet count
Ankylosing spondylitis
