摘要
目的:系统评价艾迪注射液、复方苦参注射液、康莱特注射液、榄香烯注射液和鸦胆子油乳注射液治疗恶性胸腔积液(MPE)的疗效,为临床提供循证参考。方法:计算机检索PubMed、EMBase、Cochrane图书馆、中国期刊全文数据库(CJFD)、万方数据库和中文科技期刊数据库,收集艾迪注射液、复方苦参注射液、康莱特注射液、榄香烯注射液和鸦胆子油乳注射液分别对比顺铂治疗MPE的随机对照试验(RCT),提取资料并按照改良的Jadad评分量表评价质量后,采用ADDIS 1.16.6统计软件进行网状Meta分析。结果:共纳入54项RCT,合计3 404例患者。所有研究均为双臂,总臂数为108。网状Meta分析结果显示,与顺铂相比,复方苦参注射液[OR=2.19,95%CI(1.30,3.76),P<0.05]、榄香烯注射液[OR=3.55,95%CI(2.43,5.32),P<0.05]和鸦胆子油乳注射液[OR=1.92,95%CI(1.34,2.76),P<0.05]可以显著提高MPE患者有效率,差异均有统计学意义;两两比较显示,榄香烯注射液在提高MPE患者有效率方面显著优于艾迪注射液[OR=0.32,95%CI(0.17,0.56),P<0.05]、康莱特注射液[OR=0.30,95%CI(0.13,0.68),P<0.05]和鸦胆子油乳注射液[OR=1.85,95%CI(1.10,3.17),P<0.05],差异均有统计学意义;概率排序为榄香烯注射液>复方苦参注射液>鸦胆子油乳注射液>艾迪注射液=康莱特注射液=顺铂。与顺铂相比,艾迪注射液[OR=0.29,95%CI(0.16,0.54),P<0.05]、复方苦参注射液[OR=0.44,95%CI(0.18,0.96),P<0.05]、榄香烯注射液[OR=0.21,95%CI(0.10,0.44),P<0.05]和鸦胆子油乳注射液[OR=0.41,95%CI(0.23,0.70),P<0.05]可以显著提高MPE患者生存质量改善率,差异均有统计学意义;两两比较显示,榄香烯注射液在提高MPE患者生存质量改善率方面显著优于康莱特注射液[OR=4.84,95%CI(1.03,25.01),P<0.05],差异有统计学意义;概率排序为榄香烯注射液>艾迪注射液>复方苦参注射液>鸦胆子油乳注射液>康莱特注射液>顺铂。结论:5种中药注射液均能有效治疗MPE,改善患者生存质量,其中榄香烯注射液成为最有效干预措施的可能性最大。
OBJECTIVE： To evaluate therapeutic efficacy of Aidi injection, Compound kushen injection, Kanglaite injection, Elemene injection and Brucea javanica oil emulsion injection in the treatment of malignant pleural effusion （MPE）, and to provide evidence-based reference in clinic. METHODS： Retrieved from PubMed, EMBase, Cochrane library, CJFD, Wanfang database and CJFD, RCTs about Aidi injection, Compound kushen injection, Kanglaite injection, Elemene injection and B. javanica oil emulsion injection in the treatment of MPE were collected. Meta-analysis was conducted by using ADDIS 1.16.6 statistical software after data extraction and quality evaluation by modified Jadad scale. RESULTS： A total of 54 RCTs were included, involving 3 404 patients. All RCTs were two legs with a total number of 108. Results of network Meta-analysis showed that compared with cisplat- in, Compound kushen injection [OR=- 2.19,95 % CI （1.30,3.76）, P〈 0.05], Elemene injection [OR=- 3.55,95 % CI （2.43,5.32）, P〈 0.05] and B. javanica oil emulsion injection [OR= 1.92,95%CI（1.34, 2.76）,P〈0.05] could significantly improve response rate of MPE patients, with statistical significance. Pairwise comparison showed response rate of Elemene injection was significantly higher than that of Aidi injection [OR=0.32,95%CI（0.17,0.56） ,P〈0.05], Kanglaite injection [OR=0.30,95%CI（0.13,0.68） ,P〈0.05] and B. javanica oil emulsion injection [OR=1.85,95%CI（1.10,3.17）,P〈0.05] in improving response rate. The probability ranking was Elemene injection〉Compound kushen injection〉B, javanica oil emulsion injection〉Aidi injection=Kanglaite injection=cisplatin. Compared with cisplatin, Aidi injection [OR=0.29,95% CI（0.16, 0.54）,P〈0.05], Compound kushen injection [OR=-0.44, 95% CI（0.18,0.96） ,P〈0.05], Elemene injection [OR=0.21,95% CI（0.10,0.44） ,P〈0.05] and B. javanica oil emulsion injection [OR=-0.41,95%CI（0.23,0.70） ,P〈0.05] could significantly improve the rate of quality of life improvement in MPE patients, with statistical significance. Pairwise comparison showed the rate of quality of life improvement of Elemene injection in MPE patients was significantly higher than that of Kanglaite injection [OR= 4.84,95 % CI（1.03,25.01）, P〈0.05]. The probability ranking was E1- emene injection〉Aidi injection〉Compound kushen injection〉B, javanica oil emulsion injection〉Kanglaite injection〉cisplatin.CONCLUSIONS： All 5 kinds of TCM injection can effectively treat MPE and improve the quality of life, among which E1-emene injection is mostlikely to be the most effective intervention.
出处
《中国药房》
CAS
北大核心
2017年第33期4686-4690,共5页
China Pharmacy
关键词
中药注射液
恶性胸腔积液
网状Meta分析
疗效
生存质量
TCM injection
Malignant pleural effusion
Network Meta-analysis
Therapeutic efficacy
Quality of survival life
作者简介
药师。研究方向：临床药学。电话：022-27285063。E-mail：yangxiangjun890825@126．com;通信作者：副主任药师，硕士。研究方向：临床药学。电话：022-23626417。E-mail：onlyxia023@163．com
