摘要
目的探讨小剂量美托洛尔治疗重症心力衰竭的临床效果。方法选取2015年1月~2016年6月在我院接受诊治的75例重症心力衰竭患者作为研究对象,随机将其分为观察组(n=38)和对照组(n=37)。对照组患者给予常规治疗,观察组患者在常规治疗基础上联合小剂量美托洛尔治疗,比较两组患者的临床疗效。结果治疗后,观察组患者的治疗总有效率(97.37%)明显高于对照组(81.08%),差异有统计学意义(P<0.05)。治疗后,观察组患者的心率[(67.1±10.3)次/min]、舒张压[(69.8±5.8)mm Hg]均低于对照组[(75.0±12.5)次/min、(76.1±8.0)mm Hg],差异有统计学意义(P<0.05)。观察组患者的LVD[(55.3±6.6)mm]、LVS[(36.1±7.3)mm]均低于对照组[(62.9±8.5)mm,(42.0±8.1)mm],观察组患者的LVEF[(57.1±6.1)%]高于对照组[(51.9±5.5)%],差异均有统计学意义(P<0.05)。观察组患者的生活质量评分[(86.3±3.7)分]高于对照组[(72.2±5.1)分],差异有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论小剂量美托洛尔治疗重症心力衰竭效果显著,值得在临床中推广。
Objective To investigate the clinical effect of low dose Metoprolol in the treatment of severe heart failure. Methods 75 cases of patients with severe heart failure treated in our hospital from January 2015 to June 2016 were se- lected as the research objects and were randomly divided into the observation group （n=38） and the control group （n= 37）.Patients in the control group were given routine treatment while patients in the observation group were treated with small dose of Metoprolol based on the treatment in the control group.And the clinical effect was compared between the two groups.Results After treatment,the total effective rate of the observation group was 97.37%,which was significantly higher than that of the control group （81.08%）,and the difference was statistical significant （P〈0.05）.The heart rate of the patients in the observation group was [（67.1±10.3） beats per min],whieh was lower than that of the control group [（75±12.5） beats per mini,and the difference was statistical significant （P〈0.05）.The diastolic pressure of the observation group after treatment was [（69.8±5.8） mmHg],which was lower than that of the control group [（76.1±8.0） mmHg],and the difference was statistical significant （P〈0.05）.The observation group＇s LVD was [（55.3 ±6.6） mm],LVS was [（36.1±7.3） mm] in the observation group were lower than those of the control group [（62.9±8.5） mm,（42.0±8.1） mm],and LVEF [（57.1±6.1）%] in the observation group were higher than that of the control group [（51.9±5.5）%],and the differences were statistical significant （P〈0.05）.The quality of life score in the observation group was [（86.3±3.7） points],which was higher than that of the control group [（72.2±5.1） points],and the difference was statistical significant （P〈0.05）.There was no significant difference in the incidence of adverse reactions between the two groups （P〉0.05）.Conclusion Low dose Metoprolol is effective in the treatment of severe heart failure and deserves to be popularized in clinic.
出处
《中国当代医药》
2017年第31期137-139,142,共4页
China Modern Medicine
关键词
重症心力衰竭
小剂量美托洛尔
心功能
疗效
不良反应
Severe heart failure
Low dose Metoprolol
Cardiac function
Curative effect
Adverse reaction
作者简介
杨强凤（1990-），女，硕士，医师;通讯作者：邬艺渊（1982-），男，本科，主治医师
