摘要
目的:探讨非典型抗精神病药(AAPDs)合并丁螺环酮对精神分裂症患者的治疗作用。方法:将85例精神分裂症患者分为研究组(43例)和对照组(42例),两组在单一AAPD常规治疗基础上,研究组及对照组分别加用丁螺环酮及安慰剂,疗程12周。治疗前及治疗4、8、12周后分别给予阳性及阴性症状量表(PANSS)、韦氏成人智力量表(WAIS-R)、韦氏记忆量表(WMS)评分;治疗4、8、12周后给予治疗中出现的症状量表(TESS)评定;以PANSS减分率评价疗效。结果:治疗第8周起两组PANSS总分均较治疗前明显降低(P<0.05或P<0.01);12周末研究组PANSS总分显著低于对照组(P<0.01);总有效率(88.4%)显著高于对照组(71.4%)(P<0.05);治疗8周后两组WAIS-R总分、言语量表分、操作量表分及WMS分较治疗前明显增高,研究组改善更明显(P均<O.05)。结论:AAPDs合并丁螺环酮较单一AAPDs治疗精神分裂症可获得更好的疗效和认知功能改善,且无增加不良反应。
Objective： To explore the therapeutic effect of atypical antipsychotic drugs（ AAPDs） combined with buspirone on schizophrenia. Method： Eighty five patients with schizophrenia were divided into study group（ 43 cases） and control group（ 42 cases）. On the basis of single AAPD treatment,buspirone and placebo were added to the study group and the control group respectively for 12 weeks. The positive and negative symptom scale（ PANSS）,the Wechsler adult intelligence scale（ WAIS-R） and the Wechsler memory scale（ WMS） were administered before treatment and 4,8,12 weeks after treatment; After 4,8 and 12 weeks treatment,the treatment emergent symptom scale（ TESS） was used to assess adverse reaction. Results： After 8 weeks of treatment,the total scores of PANSS in the two groups were significantly lower than those before treatment（ P 0. 05 or P 0. 01）; The total score of PANSS in the study group was significantly lower than that in the control group at the 12 weekend（ P 0. 01）; The total effective rate（ 88. 4%） was significantly higher than that of the control group（ 71. 4%）（ P 0. 05）; After 8 weeks treatment,WAIS-R total scores,verbal as well as performance score and WMS score of two groups were significantly higher than before treatment,and the study group improved more obviously（ P 0. 05）. Conclusion： Compared with the single AAPDs treatment,AAPDs in combination with buspirone can improve the efficacy and cognitive function without adverse effects increase.
出处
《临床精神医学杂志》
2017年第5期337-339,共3页
Journal of Clinical Psychiatry
作者简介
赵霞,E-Mail：86995420@qq.com
