摘要
MiRNA-16基因位于13号染色体,属于非编码RNA,由22个核苷酸组成,可以调控核因子-κB(NF-κB)的表达。NF-κB具有多向调节作用的转录因子,如NF-κB具有调节Bcl-x等抗凋亡蛋白的表达,也可以调节肿瘤坏死受体相关因子(TRAF1)等抗凋亡基因的表达,而且对白介素-2(IL-2)等生长因子也具有一定的调节作用。因此,NF-κB与肿瘤的增殖、凋亡密切相关。miRNA-16通过与NF-κBB的启动子区域或3′UTR结合,调节NF-κB间接发挥调控抗凋亡基因、抗凋亡蛋白、生长因子的作用。本文综述了miRNA-16和NF-κB的合成与功能,以及miRNA-16潜在的抗凋亡基因、抗凋亡蛋白、生长因子等调控靶点。
The miRNA-16,gene of coding which is located on chromosome 13,belong to the non-coding RNA and con- sists of 22 nucleotides,which could regulate the expression of NF-κB.NF-κB is a muhidirectional adjustment of transcription factors,such as NF-κB couldn adjust the protein Bcl-x expression and other anti-apoptotic proteins exprsssion when also could adjust the protein IL-2 expression and other growth factors expression,also could adjust the gene- TRAF1 expression and other anti-apoptotic gene expression.Therefore,NF-κB is closely related to tumor proliferation and apoptosis.MiRNA-16 may he combined with promoter region or 3′UTR of the NF-κB,and could indirectly regulate anti-apoptotie genes,anti-apoptotic proteins and growth factors by NF-κB.The synthesis and function of mirna-16 and NF-κB were reviewed in this paper, and the potential anti-apoptotic gene,anti-apoptotic protein,growth factor and other control targets of mirna-16 were reviewed.
出处
《中国当代医药》
2017年第29期15-17,共3页
China Modern Medicine
基金
江苏护理职业学院院级立项课题(YK1702)
关键词
非编码RNA
NF-ΚB
凋亡
Non-coding RNA
Nuclear factor kappa B
Apoptosis
