摘要
血栓调节蛋白(thrombomodulin,TM)是凝血系统中重要的调节因子。其与凝血酶形成复合物后可以活化蛋白C,从而抑制凝血途径。近年来,随着凝血酶及活化蛋白C在炎症通路中调节功能的揭示,血栓调节蛋白在炎症反应、免疫功能及调节白细胞分化、黏附中的显著作用成为研究热点,并且已扩展至肿瘤领域。本文对血栓调节蛋白在上述领域的研究进展进行综述。
Thrombomodulin, a key regulator in coagulation, acts as an inhibitor to thrombogenesis through being combined with thrombin and activating protein C. In recent years, with the revealing of the fact that thrombin and activated protein C play important roles in regulating inflammation, thrombomodulin is becoming a research hot spot in inflammation, immunity, leukocyte differentiation and adhesion, which has extended to carcinoma. In this article, we aim to investigate the research advances in thrombomodulin in the areas mentioned above.
出处
《解放军医学院学报》
CAS
2017年第10期984-986,989,共4页
Academic Journal of Chinese PLA Medical School
基金
部委级资助项目
军队后勤科研计划重点项目(BHJ16J011)~~
作者简介
宋立成，男，在读硕士，医师。Email：songlicheng@tom．com
通信作者：韩志海，男，博士，主任医师。Email：hanzhihai@sohu．com
