摘要
目的通过使用meta分析法综合评估白细胞介素-6(IL-6)–174C/G基因多态性与胃癌易感性的关系。方法通过计算机检索Pub Med、Embase、The Cochrane Library、Web of Science、维普中文科技期刊数据库、CNKI学术总库和万方数据库来获取全部符合该meta分析纳入和排除标准的文献。检索均从各数据库建库开始至2017年1月。分析IL-6–174C/G基因多态性(CC vs.GG、GC vs.GG、CC+CG vs.GG、CG+GG vs.CC及C vs.G)与胃癌易感性的关系,采用Stata 12.0软件进行异质性检验和meta分析。结果共有13个病例对照研究最终纳入本meta分析,共2 062例胃癌患者和3 152例对照者。meta分析结果显示,在各基因遗传模型下,IL-6–174C/G基因多态性与胃癌易感性均无关[CC vs.GG:OR=1.33,95%CI(0.92,1.94);GC vs.GG:OR=1.32,95%CI(0.96,1.82);CC+CG vs.GG:OR=1.32,95%CI(0.97,1.80);CG+GG vs.CC:OR=0.89,95%CI(0.67,1.17);C vs.G:OR=1.22,95%CI(0.98,1.54)]。亚组分析结果显示,在亚洲人群中,IL-6–174C/G基因多态性与胃癌易感性有关[CC vs.GG:OR=1.80,95%CI(1.29,2.50);GC vs.GG:OR=1.51,95%CI(1.20,1.90);CC+CG vs.GG:OR=1.60,95%CI(1.30,1.96);CG+GG vs.CC:OR=0.60,95%CI(0.44,0.83);C vs.G:OR=1.59,95%CI(1.24,2.03)];但在欧洲人群中的各基因遗传模型下,IL-6–174C/G基因多态性与胃癌易感性均无关[CC vs.GG:OR=1.11,95%CI(0.90,1.39);GC vs.GG:OR=1.16,95%CI(0.98,1.37);CC+CG vs.GG:OR=1.12,95%CI(0.96,1.32);CG+GG vs.CC:OR=1.07,95%CI(0.88,1.30);C vs.G:OR=1.04,95%CI(0.78,1.41)]。结论在亚洲人群中,IL-6–174C/G基因多态性与胃癌的易感性存在一定的相关性,但在欧洲人群中的各基因遗传模型下,IL-6–174C/G基因多态性与胃癌易感性均无关。
Objective To investigate association between -174C/G genetic polymorphism ofinterleukin-6 （IL-6） and susceptibility to gastric cancer by conducting a meta-analysis. Methods Such databases as PubMed, Embase, The Cochrane Library, Web of Science, CNKI, VIP, and Wanfang Data were searched from inception to January 2017 to collect case-control studies about the correlation between the -174C/G genetic polymorphism of IL-6 and susceptibility to gastric cancer. For the population genotype distributions of both the gastric cancer group and the control group, their odds ratios （OR） and 95% confidence intervals （CI） were taken as the effect indexes were applied to conduct meta-analysis in the homozygote model （CC vs. GG）, heterozygote model （GC vs. GG）, dominant model （CC＋CG vs. GG）, recessive model （CG＋GG vs. CC）, and allelic genetic model （C vs. G）. Two reviewers independently screened the literatures, extracted the data, and evaluated the quality of the included studies. The meta-analysis was performed using Stata 12.0 software. Results Thirteen articles were included in the final meta-analysis, covering a total of 2 062 gastric cancer cases and 3 152 controls. The results of meta-analysis showed that there was no correlation between the IL-6 -174C/G genetic polymorphism and the risk of gastric cancer [ CC vs. GG： OR=1.33, 95% CI （0.92, 1.94）; GC vs. GG： OR=1.32, 95% CI （0.96, 1.82）; CC＋CG vs. GG： OR=1.32, 95% CI （0.97, 1.80）; CG＋GG vs. CC： OR=0.89, 95% CI （0.67, 1.17）; C vs. G： OR=1.22, 95% CI （0.98, 1.54） ] . But the results of the subgroup analysis showed there was a significant association between the IL-6 -174 C/G genetic polymorphism and the risk of gastric cancer in Asians [ CC vs. GG： OR=1.80, 95% CI （1.29, 2.50）; GC vs. GG： OR=1.51, 95% CI （1.20, 1.90）; CC＋CG vs. GG： OR=1.60, 95% CI （1.30, 1.96）; CG＋GG vs. CC： OR=0.60, 95% CI （0.44, 0.83）; C vs. G： 0R=1.59, 95% CI （1.24, 2.03） ] . However, no association was found in Europeans [ CC vs. GG： OR=1.11, 95% CI （0.90, 1.39）; GC vs. GG： OR=1.16, 95% CI （0.98, 1.37）; CC＋CG vs. GG： OR=1.12, 95% CI （0.96, 1.32）; CG＋GG vs. CC： 0R=1.07, 95% CI （0.88, 1.30）; C vs. G： OR=1.04, 95% （21（0.78, 1.41） ]. Conclusion IL-6 -174C/G genetic polymorphism is associated with susceptibility to gastric cancer in Asians, which is not associated with susceptibility to gastric cancer in Europeans.
出处
《中国普外基础与临床杂志》
CAS
2017年第10期1234-1245,共12页
Chinese Journal of Bases and Clinics In General Surgery
基金
甘肃省科技支撑计划项目(项目编号:1504FKCA084)
甘肃省卫生行业计划项目(项目编号:GSWST2013-16)
作者简介
通信作者：关泉林，Email：guanquanlinwy@163．com
