摘要
目的:观察麻黄汤加减治疗慢性支气管炎急性发作的临床疗效,以及相关炎症细胞因子的研究。方法:选取86例慢性支气管炎急性发作患者,随机分为对照组和观察组,每组43例,对照组患者予头孢地嗪2.0g静滴,1日2次,氨溴索60mg静推,1日2次,氨茶碱0.3g静脉滴注,1日1次,15天为1个疗程。观察组患者在对照组治疗的基础上给予麻黄汤加减治疗,每日1剂水煎早晚2次分服,2组均15天为1疗程。检测2组患者治疗前后血清中白介素1β(IL-1β)、γ干扰素(IFN-γ)、肿瘤坏死因子α(TNF-α)及白介素8(IL-8)的水平;观察2组患者主要症状减轻/消失时间以及治疗效果。结果:2组患者在治疗1个疗程后炎性因子的水平明显降低(P<0.05);并且IL-1β、TNF-α、IFN-γ及IL-8的含量降低程度高于对照组(P<0.05)。观察组患者的咳嗽咳痰、肺部音及喘息症状恢复时间均显著较观察组患者短(P<0.05),而发热症状的消失时间没有显著差异(P>0.05)。而观察组和对照组的治疗总有效率分别为93.0%和72.1%,有显著差异(P<0.05)。结论:麻黄汤加减治疗慢性支气管炎急性发作疗效确切,其机制可能与调节机体IL-1β、TNF-α、IFN-γ及IL-8等炎症因子有关。
Objective： To observe the clinical curative effect of using Modified Mahuang Decoction in the treatment of acute exacerbations of chronic bronchitis,research and related inflammatory cytokines. Methods： 86 cases of acute exacerbation of chronic bronchitis patients were randomly divided into controlled group and observation group,each group included 43 patients. Patients in the controlled group were treated with intravenous infusion of 2. 0 g（ bid）,intravenous injection of ambroxol 60 mg（bid）,intravenous infusion of aminophylline 0. 3 g（qd）,15 days for 1 course. Patients in the observation group was given Modified Mahuang Decoction on the basis of the controlled group. 2 times a day,the morning and evening of the 1 doses of water,the 2 groups were treated for 1 course of 15 days. Detection of two groups before and after treatment of serum interleukin 1β（ IL-1β）and interferonγ（ IFN-y）,tumor necrosis factor α（ TNF-α） and interleukin 8（ IL-8） level; observing the main symptoms of the 2 groups of patients to reduce/disappearance time and treatment effect. Results： The two groups of patients in the treatment of 1 courses of inflammatory factor levels were significantly lower（ P〈0. 05）; and IL-1β,TNF-α,IFN-γ and IL-8 content was higher than that of the controlled group（ P〈0. 05）. The observation group of patients with cough and expectoration,pulmonary rales and wheezing symptom recovery time were significantly shorter in the observation group（ P〈0. 05）,while the disappearance time of fever symptoms had no significant difference（ P〈0. 05）. The total effective rate of the observation group and the controlled group were 93% and 72. 1%,respectively（ P〈0. 05）. Conclusion： Using Modified Mahuang Decoction in the treatment of acute exacerbation of chronic bronchitis has certain effect,and its mechanism may be related to regulating the IL-1β,TNF-α,IFN-γ and IL-8 and other inflammatory factors.
出处
《四川中医》
2017年第8期68-71,共4页
Journal of Sichuan of Traditional Chinese Medicine
