摘要
目的探讨头孢哌酮钠舒巴坦钠联合左氧氟沙星在慢性支气管炎患者中的应用效果.方法选取2021年1月—2023年1月山东省泰安荣军医院收治的110例慢性支气管炎患者为研究对象,按随机数字表法将其分为对照组与观察组.对照组(n=55)静脉滴注头孢哌酮钠舒巴坦钠,观察组(n=55)在对照组的基础上静脉滴注左氧氟沙星,两组均持续治疗7d.比较两组患者的临床疗效、炎症因子水平、血气指标及不良反应发生情况.结果观察组治疗总有效率为81.82%,高于对照组的61.82%,差异有统计学意义(P<0.05).治疗后,观察组C反应蛋白水平为(8.25±1.46)mg/L、降钙素原水平为(0.43±0.21)ng/mL及肿瘤坏死因子水平为(15.03±2.14)ng/L,均低于对照组,组间差异有统计学意义(P<0.05);观察组血氧分压水平为(71.74±3.76)mmHg(1 mmHg=0.133 kPa),高于对照组,差异有统计学意义(P<0.05);二氧化碳分压水平为(40.43±2.57)mmHg,低于对照组,差异有统计学意义(P<0.05).两组不良反应发生率对比,差异无统计学意义(P>0.05).结论慢性支气管炎患者采用头孢哌酮钠舒巴坦钠与左氧氟沙星联合使用,疗效显著,值得推广.
Objective To explore the clinical effect of Cefoperazone/sulbactam combined with Levofloxacin in the treatment of chronic bronchitis.Methods 110 patients with chronic bronchitis admitted to Tai'an Military Hospital in Shandong Province from January 2021 to January 2023 were selected as the study objects and divided into control group and observation group according to random number table method.The control group(n=55)was given cefoperazone sodium and sulbactam sodium intravenously,and the observation group(n=55)was given levofloxacin intravenously on the basis of the control group.Both groups were treated continuously for 7 days.The clinical efficacy,levels of inflammatory factors,blood gas indexes and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 81.82%higher than 61.82%of the control group,the difference was statistically significant(P<0.05).After treatment,the C-reactive protein level in observation group was(8.25±1.46)mg/L,the procalcitonin level was(0.43±0.21)ng/mL and the tumor necrosis factor level was(15.03±2.14)ng/L,which were lower than those in control group,and the differences between groups were statistically significant(P<0.05);the blood oxygen partial pressure of observation group was(71.74±3.76)mmHg,which was higher than that of control group,and the difference between group was statistically significant(P<0.05);the PCO2 level was(40.43±2.57)mmHg,lower than that of the control group,and the difference between groups was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of cefoperazone sodium and sulbactam sodium with levofloxacin in patients with chronic bronchitis has a remarkable effect and is worth promoting.
作者
陈升
张鲁冬
CHEN Sheng;ZHANG Ludong(Primary disease area,Tai'an Military Hospital,Tai'an Shandong,271000,China;1st Department of Pneumology,Tai'an Cancer Prevention and Control Hospital,Tai'an Shandong,271000,China)
出处
《反射疗法与康复医学》
2023年第13期152-155,共4页
Reflexology And Rehabilitation Medicine
关键词
慢性支气管炎
头孢哌酮钠舒巴坦钠
左氧氟沙星
临床疗效
炎症因子
血气指标
不良反应
Chronic bronchitis
Cefoperazone sodium and sulbactam sodium
Levofloxacin
Clinical efficacy
Inflammatory factors
Blood gas indicators
Adverse reactions
作者简介
陈升(1989-),男,山东泰安人,本科,主治医师,研究方向:内科疾病诊疗。
