摘要
目的比较雷珠单抗玻璃体腔注射联合激光与单纯激光治疗糖尿病视网膜病变在视力恢复中的效果。方法选取2013年11月至2015年4月期间收治的80例糖尿病视网膜病变患者,按照随机数表法将分为观察组(n=40)和对照组(n=40)。其中,对照组仅给予激光治疗(532 nm绿激光),观察组在激光治疗后给予玻璃体腔雷珠单抗(一次性注射0.2 ml)治疗。观察并比较两组患者的治疗效果、最佳矫正视力、视网膜厚度变化、黄斑水肿发生率及并发症情况。结果观察组患者的治疗总有效率为95.00%,明显高于对照组的72.50%,差异有统计学意义(P<0.05)。治疗前,两组患者的视网膜厚度比较差异无统计学意义(P>0.05),治疗后,观察组患者视网膜厚度为(325.19±68.32)μm,明显低于对照组(452.20±66.30)μm,差异有统计学意义(P>0.05)。观察组患者的黄斑水肿消退情况优于对照组患者,差异有统计学意义(P>0.05)。治疗前,两组患者视力差异无统计学意义(P>0.05);治疗后,观察组患者视力提高优于对照组,差异有统计学意义(P<0.05)。观察组患者并发症发生率(12.50%)明显低于对照组(67.50%),差异有显著性(P<0.05)。结论激光治疗后采用雷珠单抗玻璃体腔注射治疗糖尿病视网膜病变患者与单纯激光治疗比较,前者能更有效地改善患者视力,减少并发症发生,安全性高。
Objective To observe and compare the Ranibizumab intravitreal injection with laser in the treatment of diabetic retinopathy in visual acuity recovery effect. Methods 80 patients with diabetic retinopathy from November 2013 to April 2015 in our hospital were researched.They were divided randomly into observation and control groups. 40 patients in the control group,using laser treatment（ 532 nm green laser）. 40 patients in the observation group,they were treated by Ranibizumab intravitreal（ disposable injection 0. 2 ml） after the laser treatment. Treatment effect,retinal thickness,best corrected visual acuity,macular edema,complications were compared. Results Treatment effect of the observation group was better than that of the control group,total effect rate of the observation group（ 95. 00 %） was higher than that of the control group（ 72. 50%）,there was significant difference（ P〈0. 05）. Before treatment,retinal thickness of the two groups had no significant difference（ P〉0. 05）. After treatment,retinal thickness of the observation group（ 325. 19 ± 68. 32） μm was lower than that of the control group（ 452. 20 ±66. 30） μm with significant difference（ P〈0. 05）. Macular edema of the observation group was better than that of the control group,there was significant difference（ P〈0. 05）. After treatment,the complication rate of the observation group（ 12. 5%） was also lower than that of the control group（ 67. 5%） with significant difference（ P〈0. 05）. After treatment,visual acuity of the observation group was improved much better than that of the control group with significant difference（ P〈0. 05）. The complication rate of observation group was 12. 50%,the control group was 67. 50%,and the former was lower（ P〈0. 05）. Conclusion Compared with laser in the treatment of diabetic retinopathy,Ranibizumab curative effect is distinct,can more effectively improve the visual acuity of the patients,reduce the incidence of complications and safe.
出处
《临床和实验医学杂志》
2017年第18期1800-1802,共3页
Journal of Clinical and Experimental Medicine
基金
2012年海南省卫生厅项目(编号:琼卫2012-45)
