摘要
目的研究急性脑梗死不同时期的Apelin-13水平及其与热休克蛋白70(HSP-70)、β内啡肽(β-EP)及临床预后的关系。方法选取2015~2016年收治的急性脑梗死患者(观察组)与同期体检者(对照组)各60例,检测对照组与观察组不同时期(入院第1、3、7、15、30天)的Apelin-13、HSP-70、β-EP水平及其相关性,同时分析不同预后观察组的GCS、APACHEⅡ以及NHISS评分。结果观察组患者不同时期的Apelin-13、HSP-70明显高于对照组,差异有统计学意义(P<0.05),β-EP则无显著差异(P>0.05)。观察组患者的Apelin-13与HSP-70表现为负相关性(P<0.05),观察组Apelin-13以及HSP-70均与β-EP无明显的相关性(P>0.05)。观察组不同预后患者的β-EP无显著差异(P>0.05),而Apelin-13、HSP-70、GCS评分、APACHEⅡ评分、NHISS评分均存在显著差异(P<0.05)。结论 Apelin-13在急性脑梗死患者发病首日明显降低,之后逐渐升高,HSP-70则在发病首日升高,之后逐渐降低。预后较差的患者Apelin-13以及GCS较低,而HSP-70、APACHEⅡ评分、NHISS评分较高,可以用作急性脑梗死患者预后的判定指标。
Objective To study the relationship between levels of Apelin - 13, heat shock protein 70 （ HSP - 70） and beta - endorphin （ beta EP） and prognosis of patients with acute cerebral infarction in different periods. Methods A total of 60 patients with acute cerebral infarc- tion and 60 healthy persons during 2015 to 2016 were included in this study. The levels of Apelin - 13, HSP -70 and beta - EP were detected, and their correlation had been detected and analyzed in different periods （1, 3,7, 15 and 30 days after admission） between these 2 groups, and GCS, APACHE II and NHISS scores were analyzed with different prognosis of patients in observation group. Results Levels of Apelin - 13 and HSP - 70 in patients of observation group in different periods were significantly higher than those of control group, and the difference was statisti- cally significant （ P 〈0.05）, but there was no significant difference in levels of 13 -EP （ P 〉 O. 05 ）. Levels of Apelin- 13 and HSP- 70 showed negative correlation （ P 〈0.05） in patients of observation group, the levels of Apelin - 13 and HSP -70 in patients of observation group were not significantly correlated with level of 13 - EP （ P 〉 0.05 ）. There was no significant difference in 13 - EP scores （ P 〈 0, 05 ） among pa-tients with different prognosis in observation group （ P 〉0.05 ）, but there was signficant difference in levels of Apelin - 13 and HSP - 70 and GCS scores, APACHE scores and NHISS scorest. Conclusion Level of Apelin - 13 was significantly decreased in patients with acute cerebral in- farction in first day of onset, then it is rising, level of HSP -70 is higher in first day of onset, then it gradually reduced. The levels of Apelin - 13 and GCS scores are low in patients with poor prognosis, and levels of HSP -70, APACHE Ⅱ scores and NHISS scores are higher, hence they can be used as markers for judgement of the prognosis of patients with acute cerebral infarction.
出处
《临床和实验医学杂志》
2017年第17期1719-1722,共4页
Journal of Clinical and Experimental Medicine
