摘要
目的:建立微波消解-电感耦合等离子体质谱法(ICP-MS)测定动物类中药中的Pb、Cd、As、Hg、Cu等5种有害元素的方法。方法:样品经HNO_3-H_2O_2微波消解后,优化了电感耦合等离子体质谱仪工作参数,基体干扰和质谱干扰分别通过使用Ge、In、Bi内标溶液和碰撞反应池技术(KED模式)消除。结果:5种有害元素的检出限在0.04~0.52μg·L^(-1),方法精密度(RSD)为1.1%~4.8%,回收率为92.4%~110.0%。利用本方法对40批次的动物类中药中的5种有害元素进行了测定,结果表明某些动物类中药的有害元素含量较高。结论:本方法快速灵敏准确,适用于动物类中药中的有害元素的分析。
Objective： To establish a method to determine 5 hazardous elements in animal traditional Chinese medicines （TCM） by microwave digestion-inductively coupled plasma mass spectrometry （ICP-MS）. Methods： HNO3-H2O2was used to decompose ani- mal TCM, the working parameters of ICP-MS were optimized, and the matrix effect and the mass spectrum interferences were corrected by the in-line addition of Ge, In and Bi internal standard solution and the collided reaction cell technology （ KED mode）, respectively. Results： The detection limits of 5 hazardous elements were within the range of 0.04-0.52 μg L-l, the relative standard deviations （RSD） were within the range of 1.1%-4.8% , and the recoveries were within the range of 92.4%-110.0%. The method was applied to determine the 5 hazardous elements in 40 batches of animal TCM. The results indicated that some kinds of hazardous elements in an- imal TCM were high, and more attention should be paid to the problems in the production and use of animal TCM. Conclusion ： The analysis method is simple, rapid and accurate, and suitable for the determination of hazardous elements in animal TCM.
出处
《中国药师》
CAS
2017年第8期1482-1485,共4页
China Pharmacist
基金
广西壮族自治区食品药品监督管理局食品药品安全科研项目(编号:桂食药监科评[2015]20号)
作者简介
通讯作者：张治军Tel：（0773）2267161E-mail：770013802@qq．com
