摘要
建立了电感耦合等离子体质谱（ICP-MS）法同时检测23种中药材中Be、Al、V、Cr、Mn、Fe、Co、Ni、Cu、Zn、As、Se、Mo、Ru、Pd、Ag、Cd、Sn、Sb、Te、Ba、Nd、Dy、Er、Ir、Hg、Tl、Pb和U等29种元素。以硝酸∶盐酸（4∶1）为消解试剂,采用微波消解法进行前处理,在线加入内标消除基体效应,运用碰撞反应池技术消除多原子分子干扰,针对不同元素选择正常和氦气碰撞反应2种模式。结果 29种元素测定重复性的RSD均小于32.4%,回收率为69.8%~121.8%,检测限为0.000 3~0.609 mg/kg。
An inductively coupled plasma mass spectrometer （ICP-MS） method was established for the determination of 29 elements, such as Be, Al, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Se, Mo, Ru, Pd, Ag, Cd, Sn, Sb, Te, Ba, Nd, Dy, Er, Ir, Hg, Tl, Pb, and U in 23 kinds of traditional Chinese medicines. The samples were digested by nitric acid . hydrochloric acid （4 ： 1） with microwave. The matrix and spectra interference of the ICP-MS were eliminated by online internal standard addition and octopole reaction/collision cell. Normal and helium collision reaction mode were selected for different elements. The RSDs of repeatabilities for 29 elements in different parts of traditional Chinese mdicines were all less than 32.4 %. Their average recoveries were in the range of 69.8 % - 121.8 %. Their limits of detection were 0.000 3 - 0.609 mg/kg.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2015年第9期999-1003,共5页
Chinese Journal of Pharmaceuticals
基金
国家"重大新药创制"科技重大专项(2009ZX09502-024和2012ZX09304005)
国家自然科学基金青年基金(81202887)
关键词
电感耦合等离子体质谱
中药材
无机元素
测定
微波消解
inductively coupled plasma mass spectrometer （ICP-MS）
traditional Chinese medicine
inorganicelement
determination
microwave digestion
作者简介
李丽敏（1975-），女，主管药师，主要从事中药、食品及化妆品的元素分析及其质量控制研究。Tel：021-38839900×26127E—mail：lilimin_sifdc@163．com.
通信联系人：季申（1963-），女，主任药师，主要从事中药代谢中药、食品及化妆品安全质量控制等研究。Tel：021-38839900×26601E—mail：jishen2012@163．com
