摘要
miRNA（miR）是一类长18-24个核苷酸的非编码小RNA,通过与其靶mRNA分子的3＇UTR互补配对,使目标mRNA分子受到翻译水平调控或直接导致其降解。每个miRNA可能靶向数个到数百个mRNA,其中30%的mRNA受到miRNA的调控。有学者研究表明miRNA表达失调在各种肿瘤的发生、发展过程中起着重要的作用,可能成为理想的肿瘤治疗靶点。
MiRNA（miR）is a non-coding small RNA of 18to 24nucleotides in length.By pairing with 3＇UTR of its target mRNA molecule,miRNA regulateS the target mRNA molecule in the translation level or directly lead to its degradation.Each miRNA may target several to several hundred mRNAs,of which 30%of the mR-NA is regulated by miRNAs.Some studies have shown that miRNA expression disorders play an important role in the development and progression of various tumors and may be the ideal target for tumor therapy.It has been shown that abnormal expression of RNA（miRNA）plays an important role in the occurrence and development of laryngeal cancer.Wang Ping found 47kinds of miRNA expression abnormalities in laryngeal cancer tissue with microarray chip detection,that of which high expression were 23kinds and low expression were 24kinds.MiRNAs that are abnormally expressed in laryngeal squamous cell carcinoma are expected to be a new marker for early diagnosis of laryngeal cancer.In this review,we summarized the progress in recent three years on the association of miRNA and the biological behaviors of laryngeal cancer.
出处
《临床耳鼻咽喉头颈外科杂志》
CAS
北大核心
2017年第14期1134-1139,共6页
Journal of Clinical Otorhinolaryngology Head And Neck Surgery
作者简介
审校者,通信作者：彭韶平，E—mail：psp666@126．com
