摘要
目的研究黄芩苷对呼吸道合胞病毒(RSV)感染的BALB/c小鼠干扰素(IFN)-α及IFN-β表达的干预作用,探讨其抗病毒机制。方法建立BALB/c小鼠呼吸道合胞病毒感染模型,采用酶联免疫吸附试验(ELISA)法检测小鼠肺组织IFN-α及IFN-β的水平。结果黄芩苷能明显增加RSV感染BALB/c小鼠的IFN-α及IFN-β的表达。结论黄芩苷在小鼠体内可以通过调控IFN的表达来发挥抗RSV的作用。
Objective To research the effect of the baicalin to the expression of interferon（IFN）-α and IFN-β in the BALB/c mouse infected by respiratory syncytial virus（RSV）,and discussed the antiviral of mechanism.Methods To establish the BALB/c mouse model of RSV,the effects of IFN-αand IFN-β in the BALB/c mouse infected by RSV were detected by ELISA.Results The IFN-αand IFN-β in the BALB/c mouse infected by RSV could be evaluated significantly by Baicalin.Conclusion The Baicalin regulates the level of IFN in the BALB/c mouse infected by RSV.
出处
《国际检验医学杂志》
CAS
2017年第14期1907-1909,共3页
International Journal of Laboratory Medicine
基金
广东省中医药局基金资助项目(20152126)
作者简介
詹铀超,男,主管技师,主要从事临床检验研究.
通信作者,E-mail：qinshen1978@163.com.
