摘要
[目的]综述近5年来相关国内实验研究成果,并根据RSV发病机制进一步总结现今国内研究本病的主要方向以更好地优化中医药对于呼吸道合胞病毒的治疗方案。[方法]文章从中药复方和中药单体两方面入手,根据呼吸道合胞病毒的发病机制分节论述了体内试验和体外实验的相关丰富的研究成果。[结果]通过归纳、总结发现,无论是中药单体还是复方研究,对于呼吸道合胞病毒研究成果均取得了巨大的成果,但是实验研究多局限于抑制病毒的增值、复制以及抑制炎症渗出这两大方面,缺乏更深层侧的分子生物学研究成果,使中医治疗呼吸道合胞病毒研究显得过于单一,不能更为广泛的被业界所认同。[结论]我们需要肯定中医药对于呼吸道合胞病毒的治疗的安全性和疗效性,但同时必须认识到中医药由于其自身成分的复杂性以及实验设计的不合理性等诸多因素的存在,使得研究进展存在诸多问题,因此我们必须认识到自身的不足,更为深入的去探讨其作用机理,并为我们今后同各种研究指明方向。
[Objective] The better optimization of traditional Chinese medicine for the treatment of respiratory syncytial virus, in the past five years is re-viewed in this paper, also the related domestic experimental research results, and according to the pathogenesis of RSV, it further summarizes the current domestic research for the main direction of the disease. [Methods] The article from the two aspects of compound Chinese medicine and traditional Chinese medicine monomer, according to the pathogenesis of respiratory syncytial virus section, discusses the experiment in vivo and in vitro related rich research results. [Results] It is found by inducing and summarizing, whether individual or compound traditional Chinese medicine, for respiratory syncytial virus re-search has made great achievement, but with experimental study limited to suppress the virus more value-added; replication and inhibiting inflammatory infiltrates the two big aspects, lacking of deeper side of molecular biology research, making the traditional Chinese medicine in the treatment of respiratory syncytial virus research appear too single, not a broader recognition by the industry. [Conclusion] We need to be sure the safety of traditional Chinese medicine for the treatment of respiratory syncytial virus and curative effect, but at the same time must recognize that because of the complexity of its com-position and design of experiment of traditional Chinese medicine, the irrationality of the existence of many factors, it makes progress with many problems, so we must be aware of their own insufficiency, more in-depth explore its mechanism of action, with al kinds of research direction in the future for us.
出处
《浙江中医药大学学报》
CAS
2014年第2期227-229,232,共4页
Journal of Zhejiang Chinese Medical University
基金
江苏省中医院院级课题(Y12049)~~
作者简介
通讯作者：袁斌，E—mail：yuanbin68358@163．com
