摘要
目的 分析九味羌活丸联合沙美特罗替卡松治疗慢性阻塞性肺疾病的疗效.方法 研究对象为2016年1月-2016年12月在我院就治的136例慢性阻塞性肺疾病患者,按照奇偶数分为观察组和对照组,各68例.2组均接受常规方案进行治疗,观察组另服用九味羌活丸,以分析九味羌活丸对该疾病的疗效.结果 观察组的总有效率为94.12%,高于对照组79.41%（P〈0.05）.经治疗,观察组FEV1/预计值、FEV1/FVC分别为（66.32±4.27）、（71.15±4.41）%,均高于对照组（58.37±4.19）、（65.16±4.30）%（均P〈0.05）.经治疗,观察组6MWT和CAT得分分别为（319.1±19.5）m、（19.15±2.97）分,均优于对照组（287.4±18.0）m、（23.01±3.08）分（均P〈0.05）.经治疗,观察组血清IL-8、TNF-α和hs-CRP水平分别为（13.40±4.05）ng/L、（18.64±4.21）ng/L、（10.91±2.59）mg/L,均低于对照组（18.92±4.27）ng/L、（25.13±4.48）ng/L、（14.67±2.75）mg/L（均P〈0.05）.治疗期间,观察组总不良反应率为2.94%,略低于对照组5.88%,但差异无统计学意义.结论 九味羌活丸可提高慢性阻塞性肺疾病治疗效果,降低患者血清炎症,改善肺功能,且不会增加不良反应.
Objective To observe the effect of of Jiuweiqianghuo pill combined with salmeterol fluticasone propionate on chronic obstructive pulmonary disease.Methods136 patientswith chronic obstructive pulmonary disease from January 2016 to December 2016 were grouped two groups by admission sequence.Two groups were treated with routine treatment and observation group was treated another with Jiuweiqianghuo pill to analyse its effect.ResultsThe total effective rate of observation group was 94.12%,higher than control group 79.41%（P〈0.05）.FEV1/ expected value and FEV1/FVC of observation group were（66.32±4.27）,（71.15±4.41）%,higher than that of control group（58.37±4.19,65.16±4.30）%（P〈0.05）.6MWT and CAT score of observation group were（319.1±19.5m,19.15±2.97points）,better than that of control group（287.4±18.0）m,（23.01±3.08）points（P〈0.05）.IL-8,TNF-α and hs-CRP level of observation group were（13.40±4.05）ng/L, （18.64±4.21）ng/L, （10.91±2.59）mg/L,lower than that of control group（18.92±4.27）ng/L, （25.13±4.48）ng/L, （14.67±2.75）mg/L（P〈0.05）.Adverse reactions rate of observation group was 2.94%,slightly lower than control group with 5.88%.ConclusionJiuweiqianghuo pill can decreased serum inflammation and improve lung function to improve the therapeutic effect of chronic obstructive pulmonary disease and it does not increase adverse reactions.
作者
王安平
WANG An-ping(Department of Internal Medicine, Second People＇s Hospital of Lishui City, Lishui 323000, Chin)
出处
《中国生化药物杂志》
CAS
2017年第6期144-146,共3页
Chinese Journal of Biochemical Pharmaceutics
关键词
九味羌活丸
沙美特罗替卡松
慢性阻塞性肺疾病
炎症
Jiuweiqianghuo pill
salmeterol fluticasone propionate
chronic obstructive pulmonary disease
inflammation
作者简介
王安平，通信作者，男，本科，主治医师，研究方向：普道内科，E—mail：callkkwO@sina．com
