摘要
文献研究表明人参皂苷能有效预防肺癌的发生发展,但大多数人参皂苷在人体内需经肠道菌群水解才能产生抗肺癌活性。肠道菌群水解人参皂苷产生的代谢产物主要通过抑制细胞增殖、抑制肿瘤血管生成以及肿瘤细胞的迁移等机制来实现抑制癌症的作用。本文就近年来人参皂苷对肺癌的防治作用、人参皂苷防治肺癌的活性与构效关系、肠道菌群对人参皂苷在肺癌防治方面活性影响及其作用机制等方面的研究进行综述分析,期望本文能为人参皂苷防治肺癌的临床个体化治疗提供实验依据。
It has been extensively investigated that ginsenosides have the functional capacity of inhibiting lung cancer cell growth,inducing angiogenesis,delaying invasion and metastasis.However,the most of the ginsenosides are able to exhibit anticancer activity when hydrolyzed by the intestinal flora in vivo.The metabolites could inhibit tumor growth by inhibiting cancer cell proliferation,which is related with inducing apoptosis and autophage of cancer cells,inhibiting proliferative signaling pathways,and by depressing antiangiogenesis and delaying invasion and metastasis.This review aims at providing an overview of the ginsenoside biotransformation by gut flora,as well as their different anticancer effects,thus providing a theoretical foundation for the indicidualized therapies for lung cancers.
出处
《中药药理与临床》
CSCD
北大核心
2017年第1期216-221,共6页
Pharmacology and Clinics of Chinese Materia Medica
基金
2014年湖北省中青年创新团队项目(编号:T201414
武当山区道地中药材GAP关键技术研究)
2017年湖北省卫计委科研项目(编号:WJ2017F079
基于小柴胡汤调控肝肠循环以降低伊立替康肠毒性机理研究)
十堰市太和医院精准医疗项目(编号:2016JZ18
抗肺癌药物伊立替康在人肺癌组织-癌旁组织微粒体中代谢表型差异与羧酸酯酶基因多态性的关联性研究)
关键词
人参皂苷
肠道菌群
肺癌
Ginsenoside（人参皂苷）
intestinal flora
lung cancer
